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Related to RUNX2: RUNX1
RUNX2Runt-Related Transcription Factor 2 (gene)
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qRT-PCR results of cell differentiation showed that miR-221 overexpression significantly increased the expression of Runx2 and Ocn on days 7 and 14, whereas miR-221 suppression showed opposite results (P<0.05, Figure 4A and B).
In vitro studies have shown that IL-1 and TNF-a enhance the expression of Wnt signaling and BMP2 in osteoblasts.[21] IL-1 can also stimulate ALP activity and mineralization by inducing a mechanism that is independent of Runx2 in VSMCs.[22] IL-6 can promote TNF-a expression and increase Runx2 expression associated with sodium-dependent phosphate transporter 1 (PiT1) and aid calcium deposition in mice.[23] Persistent activation of the inflammatory response leads to activation of inflammation-related signaling pathways, macrophages, and T-lymphocytes, thereby leading to the osteoblast-like differentiation of VSMCs.[24] Studies have shown that levels of pro-inflammatory factors in the peripheral blood such as CRP and TNF-a are increased significantly in CAC patients.
Similarly, the expression of ALP, COL1 and RUNX2, markers of fibroblast differentiation and bone formation, was also not significantly different between the groups, although the expression of RUNX2 in the cells exposed to PC 15% was notably higher.
The role of DMP-1 signaling has been well studied; after endocytosis by preodontoblasts, DMP-1 induces calcium release from the endoplasmic reticulum, activating the p38 pathway and RUNX2 nuclear translocation, which are responsible for initiating the transcription of odontogenesis-related genes [24].
The number of cells and the productions of OCN and RUNX2 on micro/nanostructured surfaces (E and EA) after 7 days of osteoinduction were higher than those on the micron/submicron-structured surface (SLA).
Remarkably, together with enhanced level of RUNX2, ALP, and OSX, there was an overexpression of CEMP1, which is a novel cementum component exclusively expressing for cementoblasts and their progenitors.
Shan, "The overexpression of miR-30a affects cell proliferation of chondrosarcoma via targeting Runx2," Tumor Biology, vol.
In agreement with the physiological role of RUNX2 in osteoblast function [38], we did not observe an increase of RUNX2-positive cells in Micro+ with respect to Micro- lesions.
Xu, "Downregulated LncRNA-ANCR promotes osteoblast differentiation by targeting EZH2 and regulating Runx2 expression," Biochemical and Biophysical Research Communications, vol.
The slices were incubated in a humid atmosphere with diluted primary antibodies (Dkk-1, GSK-3[beta], [beta]-catenin, PPAR[gamma]2, and Runx2) at 37[degrees]C for 45 min, washed 3 times with PBS, and then incubated with biotin-conjugated secondary antibody at 37[degrees]C for 45 min.
The mRNA expression of the osteogenic differentiation factors RUNX2, OPN, and OCN increased gradually as the culture time increased.
OC, ON, Col I, and Runx2 are major phenotypic markers for preosteoblast differentiation during bone formation.