RVLMRostral Ventrolateral Medulla
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(17-19) Previous research has indicated a relation between the CnF and the central areas involved in cardiovascular modulation including the RVLM, NTS, periaqueductal gray matter, and parabrachial/Kolliker-Fuse complex.
Se sabe que el nucleo fastigio cumple un importante papel en la regulacion del sistema nervioso autonomo, pues este nucleo proyecta a estructuras del tallo cerebral como el RVLM, el cual a su vez recibe inervacion del NPV y nucleo supraoptico (NSO) hipotalamico (50).
The site of action of Moxonidine in the CNS is thought to be the rostral ventrolateral medulla (RVLM), an area of the medullary reticular formation that contains neurones which control the preganglionic sympathetic neurons in the spinal cord.
It has been widely established that the rostral ventrolateral medulla (RVLM), containing the sympathetic promoter neurons, is responsible for the central control of sympathetic vasomotor tone and blood pressure (BP) [8, 9].
We recently reported that [H.sub.2]S exerts its cardiovascular effects by decreasing oxidative stress via inhibition of NADPH oxidase activity in the rostral ventrolateral medulla (RVLM) of SHRs [14].
Ongoing activity of premotor rostral ventrolateral medulla (RVLM) neurons is responsible for the tonic generation of sympathetic vasomotor tone; inhibition of RVLM neurons causes a large decrease in both arterial blood pressure (BP) and sympathetic nervous system activity, while stimulation of this medullary region increases sympathetic vasomotor outflow and BP [2, 3].
The rostral ventrolateral medulla (RVLM) is a key region involved in the central control of sympathetic outflow and plays an important role in maintaining resting BP and sympathetic tone [8].
The brainstem nuclei involved in regulation of baroreflex and autonomic function such as the nucleus of solitary tract (NTS) and RVLM [45] may also contribute to the protective role of RD in iSO-induced HF.
The paraventricular nucleus (PVN) is an important component that regulates sympathetic outflow via projections to the intermediolateral column of the spinal cord and the Rostral ventrolateral medulla (RVLM).
While there are many areas in the brain that contribute to the sympathetic activation and development of SSH, the paraventricular nucleus (PVN) of the hypothalamus has numerous projections to downstream brain regions such as the nucleus solitary tract [15], rostral ventrolateral medulla [3, 4] (RVLM), and spinal cord [16, 17].
The baroreflex arc is composed of multiple neural components including the aortic and carotid baroreceptors, the nucleus tractus solitarius (NTS), paraventricular nucleus of the hypothalamus (PVN), nucleus ambiguus (NA), caudal ventrolateral medulla (CVLM), and rostral ventrolateral medulla (RVLM) [16-19].
reports that estrogen replacement reduces oxidative stress in the rostral ventrolateral medulla (RVLM) as well as sympathetic outflow in ovariectomized (OVX) rats.