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RYR2Ryanodine Receptor 2 Gene (cardiology)
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Wu et al., "Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2," Science, vol.
There is also a "calcium clock" which consists of [Ca.sup.2+]-handling proteins that include the ryanodine receptor (RyR2), the sarcoplasmic reticulum-ATPase (SERCA2a), and the [Na.sup.+]/[Ca.sup.2+] exchanger (NCX1) [50, 51].
Based on two signaling pathways (Figures 3 and 4) involved in core GENs, we found that five network biomarkers, including UBC, APP, EGFR, ETS1, and RYR2, play a central role in pathogenesis and hepatocarcinogenesis in the lower progression path of Figure 1(a).
In addition, expression of RyR2 was remarkably increased in vehicle-treated AAC rats, contrasting that in vehicle sham rats.
Genes shown encode proteins associated with the contractile lattice (MYH6: [alpha]-myosin heavy chain, MYH7: [beta]-myosin heavy chain, TNNT2: cardiac troponin T) (a), development (NPPA: atrial natriuretic peptide, BNNP: brain natriuretic peptide) (b), calcium handling (PLN: phospholamban, RYR2: ryanodine receptor 2) (c), and voltage-gated ion channels (HCN4: hyperpolarization-activated cyclic nucleotidegated channel, KCNJ2: inward-rectifier potassium ion channel) (d).
Intracellular Ca2 + release channels are known as RyR2 and are largely arranged in supramolecular arrays (10-300 RyR2) separated from the sarcolemmal membrane by a dyadic subspace of ~15 nm.
miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2. Circ Res 2009;104:514-21.
PCB-95 sensitizes both RyR1 and RyR2 (Wong and Pessah 1996).
It is hypothesized that ethanol causes cerebral artery constriction by impairing RyR2 function.
Background: Calcium regulatory proteins-L-type Ca[sup]2+ channels (LTCCs), ryanodine receptor 2 (RyR2), and Na[sup]+/Ca[sup]2+ exchanger isoform 1 (NCX1) have been recognized as important protective mechanisms during myocardial ischemia-reperfusion injury (I/RI).
Mederos y Schnitzler et al., "Dantrolene rescues arrhythmogenic RYR2 defect in a patientspecific stem cell model of catecholaminergic polymorphic ventricular tachycardia," EMBO Molecular Medicine, vol.