Federoff served as Chair of the NIH Recombinant DNA Advisory Committee
Gene therapy oversight adds centralized federal review at the National Institutes of Health's Office of Biotechnology Activities and its Recombinant DNA Advisory Committee
to standard oversight of human subjects research at the researcher's institution (by the Institutional Review Board and, for some research, the Institutional Biosafety Committee) and at the federal level by the Office for Human Research Protections (National Institutes of Health, 2013).
Working from his four years of service on the Recombinant DNA Advisory Committee
, the agency that regulates genetic engineering experiments in the US, Carmen introduces the study of sociogenomics, which studies how DNA influences human behavior.
An oversight body called the Recombinant DNA Advisory Committee
, formed by the National Institutes of Health, essentially allowed science to police itself.
In this issue of the Report, Nancy King, a lawyer, bioethicist, and former member of the NIH Recombinant DNA Advisory Committee
, highlights the broad array of ethical and societal issues raised by the risk of germline gene transfer of donated gene sequences--that is, the risk that the donated DNA sequences will be passed on to offspring of the recipient, with potential harmful effects.
The National Institutes of Health Recombinant DNA Advisory Committee
(RAC) was formed immediately after the Asilomar meeting and in 1976 the NIH released its guidelines for conducting research, based on the advice of the RAC, which had decided that nonmaleficence (safety) was the only end to be considered.
One of the early efforts to police a specific genetic technology, recombinant DNA experiments, was the 1975 Asilomar Conference in California, which led to the establishment under the NIH of the Recombinant DNA Advisory Committee
Wivel, former director of the National Institutes of Health's Recombinant DNA Advisory Committee
(RAC), is an expert on the history of gene therapy and its regulation.
Most of the information that would be discovered about gene therapy trials under the proposal is already publicly discussed in open meetings of the Recombinant DNA Advisory Committee
of the National Institutes of Health, the FDA said.
4) The main federal committee, the Recombinant DNA Advisory Committee
, is still in existence and has been instrumental in shaping the direction of gene therapy.
In June, the National Institutes of Health Recombinant DNA Advisory Committee
gave Lotze permission to pursue IL12 gene therapy.