RHEB


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AcronymDefinition
RHEBRAS-Homolog Enriched in Brain
RHEBRight Hand Equipment Bay (US NASA)
RHEBRelevent Higher Education Body (UK)
References in periodicals archive ?
This would allow the lysosomes to get mTOR and RHEB together.
Once this had occurred, lysosomes were sent back toward the nucleus, mTOR was activated by RHEB, and cellular processes were switched back on.
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins.
The BCAA leucine activates mTORC1 by inducing its translocation to the lysosomes and interaction with the GTP-bound protein Ras homolog enriched in the brain (Rheb).
Kim et al., "Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydro genase-mediated regulation of Rheb," Molecular and Cellular Biology, vol.
EZP Regulated Rheb and Tuberin Expression in Liver Tissues of Rats with 2-AAF/PH-Induced Liver Injury.
First, AMPK phosphorylates tuberous sclerosis complex-2 (TSC2) [39] which converts the Ras homolog enriched in the brain (RHEB), a GTP-binding protein, activating upstream mTORC1, to its inactive GDP-bound form.
Species Name Unit [x.sub.1] miR451 pmol [L.sup.-1] [x.sub.2] MO25 mRNA pmol [L.sup.-1] [x.sub.3] MO25 miRNA bound pmol [L.sup.-1] [x.sub.4] MO25 pmol [L.sup.-1] [x.sub.5] LKB1-STRAD pmol [L.sup.-1] [x.sub.6] AMPK phosphorylated pmol [L.sup.-1] [x.sub.7] TSC2 phosphorylated pmol [L.sup.-1] [x.sub.8] Rheb active pmol [L.sup.-1] [x.sub.9] mTOR C1 active pmol [L.sup.-1] [x.sub.10] Glucose g[L.sup.-1] TABLE 5: The reaction parameters (DC: dimensionless constant).
Rheb (Ras homolog enriched in brain) GTPase directly binds to the catalytic domain of mTOR and acts as a positive regulator of mTORC1 kinase activity [26].
Yoon et al., "Phospholipase D1 is an effector of Rheb in the mTOR pathway," Proceedings of the National Academy of Sciences of the United States of America, vol.
mTOR is found in two protein complexes: TORC1 (mTOR, GGL/LST8, raptor, rheb), which is important for cell growth and TORC2 (mTOR, G[beta]L, rictor), which is involved in cytoskeleton orgranization (33).
Interestingly, GluN3A interacts with the small GTPase Ras homologue enriched in brain (Rheb).