Rostral ventrolateral medulla
. Stroke-prone spontaneously hypertensive rats.
Immunoreactivity of APA was distributed in the rostral ventrolateral medulla
and ambiguous nucleus and was observed in the cytoplasm of neurons and neuropils.
Chan, "Redox-sensitive oxidation and phosphorylation of PTEN contribute to enhanced activation of PI3K/Akt signaling in rostral ventrolateral medulla
and neurogenic hypertension in spontaneously hypertensive rats," Antioxidants and Redox Signaling, vol.
Exercise training improves the altered renin-angiotensin system in the rostral ventrolateral medulla
of hypertensive rats.
Our previous study has shown that CBS immunoreactivity was found in the rostral ventrolateral medulla
(RVLM) neurons in vivo and the level of CBS proteins in the RVLM was lower in SHRs than in WKY rats .
Toney, "In vivo discharge properties of hypothalamic paraventricular nucleus neurons with axonal projections to the rostral ventrolateral medulla
," Journal of Neurophysiology, vol.
It has been shown that presympathetic neurons in autonomic nuclei in the hypothalamus and rostral ventrolateral medulla
provide excitatory drive to sympathetic outflow in hypertension.
The same study noted reduced spontaneous discharge rate of neurons in the paraventricular nucleus of the hypothalamus (PVN) and the rostral ventrolateral medulla
(RVLM), two critical nuclei involved in sympathetic regulation of the cardiovascular system.
Ongoing activity of premotor rostral ventrolateral medulla
(RVLM) neurons is responsible for the tonic generation of sympathetic vasomotor tone; inhibition of RVLM neurons causes a large decrease in both arterial blood pressure (BP) and sympathetic nervous system activity, while stimulation of this medullary region increases sympathetic vasomotor outflow and BP [2, 3].
Hao et al., "Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla
in hypertensive rats," American Journal of Physiology: Heart and Circulatory Physiology, vol.
Wang et al., "Sympathoinhibitory mechanism of moxonidine: role of the inducible nitric oxide synthase in the rostral ventrolateral medulla
," Cardiovascular Research, vol.
The rostral ventrolateral medulla
(RVLM) is a key region involved in the central control of sympathetic outflow and plays an important role in maintaining resting BP and sympathetic tone .