References in periodicals archive ?
All three members of the RyR family (RyR1, RyR2, and RyR3), however, are present in the VSM of not only the thoracic aorta [15] but also the mesenteric arteries [15], the large cerebral arteries [16], and the cerebral microcirculation [5].
A previous study reported that RyR type-3 (RyR3) knockout mice exhibited impairments of performance in contextual fear conditioning, passive avoidance, and Y-maze learning tests [64].
The calcium-related protein RyR3 mRNA transcript levels increased 2.5 [+ or -] 0.4 fold in vascular tissue of 9-week-old rats compared with that in 3-week-old rats.
Monoclonal antibody (mAb) 34C or C3-33 at concentrations that selectively bind to RyR1 and RyR3 (Airey et al.
Additionally, RYR3 is expressed at low levels by skeletal muscle cells (36), and it is much more sensitive to activation by caffeine compared with RYR1 (36).
Three different isoforms of ryanodine receptors are known: ryanodine receptor type 1 (RyR1; [5] OMIM 180901) and type 2 (RyR2; OMIM 180902) are produced in skeletal and cardiac muscle, respectively, whereas ryanodine receptor type 3 (RyR3; OMIM 180903) is produced in a wide range of tissue.
Briefly, samples were first exposed to a mouse monoclonal primary antibody which recognizes both RYR1 and RYR3 (34C, 1: 20; Developmental Studies Hybridoma Bank, University of Iowa) and then to a Cy3 goat anti-mouse IgG secondary antibody (Jackson ImmunoResearch Laboratories, West Grove, PA, USA).