Garlic's organosulfur compounds, including DATS, DADS, ajoene, and S-allylmercaptocysteine
(SAMC), have been found to induce cell cycle arrest when added to cancer cells during in vitro experiments.
Organosulfur compounds (OSCs) are the major active components in garlic, including the oil-soluble compounds, such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), and water-soluble fractions containing S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC) .
Previous studies have shown the correlation between garlic and OA treatment, but the effect of the major water-soluble fraction of garlic-derived S-allylmercaptocysteine (SAMC) still remains unclear.
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Lin, "Garlic-derived compound S-allylmercaptocysteine inhibits cell growth and induces apoptosis via the JNK and p38 pathways in human colorectal carcinoma cells," Oncology Letters, vol.
Meng et al., "S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-[beta] signaling pathway in cancer cells," Oncology Reports, vol.
Soh et al., "Induction of Apoptosis by the Garlic-Derived Compound S-Allylmercaptocysteine (SAMC) Is Associated with Microtubule Depolymerization and c-Jun NH2-Terminal Kinase 1 Activation," Cancer Research, vol.
Zhao, "Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway," Oncology Reports, vol.