As of April 30, DGE surveillance activities, focusing on patients with severe respiratory disease, had identified 97 patients with laboratory-confirmed S-OIV infection, including seven persons who had died.
Editorial Note: Understanding the epidemiology and clinical profiles of recent cases of S-OIV infection in Mexico can help inform regional, national, and global control measures in response to the emergence of S-OIV infection.
The clinical spectrum of S-OIV illness is not yet well characterized in Mexico.
To expedite confirmation of disease in additional patients, the World Health Organization (WHO) Influenza Collaborating Center in Atlanta, Georgia, has placed the genetic sequence of S-OIV from California in GenBank.[dagger] Specific primers for S-OIV have been developed and will be distributed through the WHO Global Influenza Surveillance Network to reference laboratories throughout the world.
Timeline of key events in detection and response to outbreak of swine-origin influenza A (H1N1) virus (S-OIV) infection--Mexico, April 12-30, 2009 Date Event April 12 Respiratory illness outbreak reported to the Pan American Health Organization (PAHO).
DOHMH conducted telephone interviews with the 44 patients with confirmed S-OIV on April 27.
Several students participating in the on-line survey (none of whom had confirmed S-OIV) reported travel to Mexico during the week before April 20; an undetermined number were symptomatic at the time of survey participation.
On April 26, DOHMH staff members began contacting all 61 NYC hospitals with medical and/or pediatric intensive care units by telephone on a daily basis to identify possible severe cases of S-OIV, defined by the presence of fever [greater than or equal to]100.4 [degrees]F ([greater than or equal to] 38[degrees] C) and at least one of the following: acute respiratory distress syndrome, pneumonia, or respiratory distress.
Editorial Note: To date, this school-based outbreak is the largest cluster of S-OIV cases reported in the United States (2).
CDC, in collaboration with industry and federal partners, is continuing to conduct routine illness detection at ports of entry with heightened awareness for travelers who might be infected with S-ON During April 19-27, 15 cases of illness in travelers entering the United States from Mexico that were clinically consistent with S-OIV infection were detected.
Department of Homeland Security, is distributing travelers health alert notices to all persons traveling to countries with confirmed cases of S-OIV infection.
CDC has issued interim guidance for nonpharmaceutical community mitigation efforts in response to human infections with S-OIV (http://www.cdc.gov/swineflu/mitigation.htm).