S6KS6 Protein Kinase
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References in periodicals archive ?
Sendo assim, os autores analisaram as respostas hormonais e de ativacao de p70 S6K para cada sujeito do grupo amostral, e puderam perceber que quanto maior os niveis de cortisol, menor a ativacao dessa proteina sinalizadora.
[71.] Surace EI, Lusis E, Haipek CA, Gutmann DH Functional significance of S6K overexpression in meningioma progression.
Hepatocyte growth was inhibited by Rap in both PHx + PBS and PHx + MSC groups at 24 h after PHx (Figures 4(h)-4(j)), which might be attributed to the inhibited expression of p-S6K (Figure 4(b)), since a previous study has shown that S6K can improve cell growth [21].
observed that treatment of GBM cell lines with rapamycin not only resulted in a time-dependent decrease of S6K phosphorylation but also caused a paradoxical increase of AKT phosphorylation on serine 473 which is known to be responsible for cell proliferation.
AS160: Akt substrate 160 kDa; GSK3: glycogen synthase kinase type 3; IRS: insulin receptor substrate; MAPK: mitogen-activated protein kinase; mTORC2: mechanistic target of rapamycin; PI-3K: phosphatidylinositol-3-kinase; PDK-1: phosphoinositide-dependent kinase; S6K: ribosomal protein S6 kinase.
Akt and p70 S6K along with activation of MEK-ERK signaling promote ubiquitination and degradation of PDCD4 [149].
Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-ctivated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation.
The role of TOR and S6K is conserved from yeast to mammals.
Meanwhile various kinases such as GSK3, PKC, PKA, ERK, mTOR, S6K, PKG, CDK5, CKII, and JNK are involved in Ser/Thr phosphorylation of IRSs.
Teleman, "PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation," Cell Metabolism, vol.
The ribosomal protein S6 kinase (S6K), a serine/threonine kinase that belongs to the AGC kinase family, is an important regulator of cell growth and cell size.
Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise.