Recent studies have showed that SASP
may contribute to cell cycle arrest through autocrine/paracrine pathways.
"GLOCK believes strongly the attributes of responsibility, teamwork, integrity and discipline learned by youth shooters are the ingredients to the development of our next generation of responsible citizens," said Ed Fitzgerald, GLOCK advertising manager and vice chairman of the SASP
board of directors, in presenting the check.
"Our explanation is that although L1s are activated relatively late in senescence, the interferon response reinforces the SASP
response and is responsible for age-associated inflammation."
2) Investigate whether SASP
factors from senescent neurons and microglia can induce paracrine senescence and if cell-to-cell contact is required.
The domain scores were highest in SPA, followed by SPL, SPT, SASP
Kurtulus and Davis  proposed multiproject scheduling rules to minimize total project delay: shortest activity of shortest project (SASP
), largest activity of largest project (LALP), activity with highest resource demand first (MAXRD), activity with maximum slack first (MAXSLK), activity with lowest precedent work, activity with highest precedent work.
Kuzmanov, "A reconfigurable beamformer for audio applications," in Proceedings of the 2009 IEEE 7th Symposium on Application Specific Processors, SASP
This proinflammatory environment is mainly due to the senescence-associated secretory phenotype (SASP
) of the senescent immune cells [42,43], resembling on the one side the processes during chronic liver injury and fibrogenesis  and on the other side the processes in mitochondria and autophagy-inflammation-cell death axis, which are quite similar to those described for alcoholic hepatitis and NASH [46-49].
Of importance, cancer-associated senescence elicits a protumorigenic milieu through the production of secretory factors, including extracellular proteases, cytokines, and chemokines, named senescence-associated secretory phenotype (SASP
In the heart microenvironment, the oxidative stress induced by hyperglycemia can lead to stem cell senescence which is characterized by the production and secretion of soluble factor SASP
(senescence-associated secretory phenotype).
Furthermore, a senescent cell develops the senescence-associated secretory phenotype (SASP
), which produces and releases pro-inflammatory cytokines, chemokines, proteases, growth factors, and other peptides., SIPS in senescent RPE cells can upregulate the proinflammatory cytokines IL-6 and IL-8 and vascular endothelial growth factor, which are involved in AMD pathogenesis. It will also be interesting to investigate the effects of GlcN on the expression of the SASP
in H[sub]2O[sub]2-treated RPE cells.
Accordingly, it has been suggested that SCs contribute to aging and ARD onset through the senescence-associated secretory phenotype (SASP
), which consists in the secretion of a variety of soluble factors, such as proinflammatory mediators and matrix-degrading molecules .