SCP3Synaptonemal Complex Protein 3
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Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3.
With SCP3, which visualizes the axial elements and the lateral elements of the SC, we evaluated the respective frequencies of the three leptotene, zygotene and pachytene stages in patients and controls, and assessed the frequencies of the main types of meiotic abnormalities observed at the pachytene stage.
Primary antibodies against the following proteins were used: SCP3 (kindly provided by Christa Heyting) used at a dilution of 1/250, BRCA1 (Abcam plc, Cambridge, UK) used at a dilution of 1/10.