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In contrast, injection of WSLP complexed with control scRNA or of PEI with NR2B-siRNA did not produce this inhibitory effect, indicating that the intrathecal injection of WSLP/NR2B-siRNA complexes can specifically inhibit NR2B gene expression in rats with chronic inflammatory pain.
Tags annotated as noncoding RNA (rRNA, tRNA, scRNA, snRNA, and snoRNA) and those containing poly (N) sequences were removed.
To confirm that the anti-inflammatory effect of 4-PG was mediated by TTP, RAW264.7 cells were transfected with scramble RNA (scRNA) and siRNA against TTP (siTTP) for 24 hours.