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SDHBSuccinate Dehydrogenase Complex, Subunit B
SDHBSouthland District Health Board (New Zealand)
SDHBSaskatoon District Health Board (Canada)
References in periodicals archive ?
Recent studies have revealed gene mutations in the succinate dehydrogenase family (SDHA, SDHB, SDHC and SDHD) as associated with pheochromocytoma, increasing the estimates to about 35% of cases having a genetic/hereditary basis.
cerevisiae) PIR N47572 Pirin (iron-binding nuclear protein) UQCRFS1 AA035338 Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 SDHB AW294107 Succinate dehydrogenase complex, subunit B, iron-sulfur (Ip) FDX1 N89718 Ferredoxin 1 FDXR J03826 Ferredoxin reductase Gene symbol Gene function OGFOD1 Iron ion binding protein; oxidoreductase OGF0D2 Iron ion binding protein; oxidoreductase 1REB2 RNA-binding protein that binds to iron-responsive elements (IRES) of mRNA species.
These provisions are primarily in the ERA to protect workers when an employer sells a business; they are not to be used as a pawn in the contracting process to support the transfer of business by an agency such as SDHB from one employer to another.
Such tumors lack mutations in KIT and PDGFRA, although a subset of pediatric patients with GIST have germline mutations in SDHB or SDHC, similar to patients with Carney-Stratakis syndrome.
Paraganglioma, neuroblastoma, and a SDHB Mutation: Resolution of a 30-year-old Mystery.
The SDHB had wanted to develop a one-stop-shop integrated family health centre (IFHC).
Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations.
All other genetic tests were not clearly identified as high priority (MET, FH, FLCN, TSC1, TSC2, SDHD, SDHC, SDHB, SDHA, PTEN).
Large size is also a risk factor and together with extraadrenal location accounts for the high risk of malignancy associated with mutations of the SDHB gene.
Both types of tumors are associated with conditions that are inherited in an autosomally dominant manner, such as: multiple endocrine neoplasia type 2 (MEN2), [2] which is due to a mutation in the RET [3] (ret proto-oncogene) protooncogene; von Hippel-Lindau disease (VHL), which is due to a mutation in the VHL (von Hippel-Lindau tumor suppressor) gene; neurofibromatosis type 1 (NF1), caused by mutation in the NF1 (neurofibromin 1) gene; and mutations in succinate dehydrogenase (SDH) subunits B, C, and D, which are encoded by the SDHB [succinate dehydrogenase complex, subunit B, iron sulfur (Ip)], SDHC (succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa), and SDHD (succinate dehydrogenase complex, subunit D, integral membrane protein) genes.
There is some evidence that tumors in patients with SDHB mutations are characterized by norepinephrine and dopamine production (18), but that evidence is based largely on measurements of the plasma catecholamines.