SDN-POASexually Dimorphic Nucleus of the Preoptic Area
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In humans, the so-called interstitial nuclei of the anterior hypothalamus (INAH1-4) are the areas proposed to correspond to the SDN-POA in rodents.
The sex and age differenges observed are specific to the SDN-POA. In the same brains, a nearby area, the suprachiasmatic nucleus, which shows a sexual difference in shape, did not display a sex or age difference in volume or in cell number.
* For nonylphenol (industrial compound identified in drinking water supplies), low-dose effects in F1 rats following dietary exposure (in utero through puberty) to 25 ppm include a decrease in SDN-POA in males, an increase in relative thymus weight, an increase in proliferation of splenic T-lymphocytes stimulated with anti-CD3, and a prolonged estrus in females.