SDN-POA

AcronymDefinition
SDN-POASexually Dimorphic Nucleus of the Preoptic Area
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The exact role of the SDN-POA and the chemical nature of the sex differences remain unknown.
Sex differences found in human brains
For nonylphenol (industrial compound identified in drinking water supplies), low-dose effects in F1 rats following dietary exposure (in utero through puberty) to 25 ppm include a decrease in SDN-POA in males, an increase in relative thymus weight, an increase in proliferation of splenic T-lymphocytes stimulated with anti-CD3, and a prolonged estrus in females.
Determination of the toxicologic significance of volume changes in SDN-POA in male rats and the relationship between estrogenic activity and stimulation of lymphocyte proliferation.
Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review. (Workshop Summary)
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