SFKS

AcronymDefinition
SFKSSecret French Kissing Society (band)
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Abbreviations: ADDA, (7R,8S)-9-acetyl-dehydrodiconiferyl alcohol; COX-2, cyclooxygenase-2; FAK, focal adhesion kinase; iNOS, inducible nitric oxide synthase; L-NMMA, [N.sup.G]-monomethyl-l-arginine; LPS, lipopolysaccharide; JNK, c-jun N-terminal kinase 1/2; MAPK, mitogen activated protein kinases; NF-[kappa] B, nuclear factor-[kappa] B; NO, nitric oxide; PP2, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; SFKs, Src family kinases.
2005), while the expression of another SFK family protein Hck was not altered.
Several lines of evidence indicate that the cortical flash involves calcium influx, helps to prevent polyspermy, and depends on proper SFK signaling (Stricker, 1996; Stricker et al., 2010c).
AMP-activated kinase; ASW, artificial seawater; CaFSW, calcium-free seawater; ER, endoplasmic reticulum; GMP, guanosine monophosphate; GV, germinal vesicle: GVBD, germinal vesicle breakdown; [IP.sub.3], inositol 1.4,5-trisphosphate: MAPK, mitogen-activated protein kinase; MPF, maturation-promoting factor; NO, nitric oxide; NOS, nitric oxide synthase: PDE, phosphodiesterase; PKA, protein kinase A; PKC, protein kinase C; PLC, phospholipase C: SFK, Src family kinase; SW.
SFKs are signaling enzymes that have long been recognized to regulate critical cellular processes, such as proliferation, survival, migration, and metastasis [8].
Inhibition of SFKs using specific inhibitors for Src PTKs (either PP2 or SU-6656) attenuated LPS-induced lung injury and capillary permeability and reduced LPS-dependent cytokine and chemokine levels in the lung and the serum [68].
Dasatinib (BMS-354825) is a selective small molecule inhibitor of SFKs and other tyrosine kinases, including Bcr-Abl, Kit, and PDGFR[beta].
Pragmin is one of the few human proteins that contain the EPIYA motif, which undergoes tyrosine phosphorylation by SFKs or CSK.
Each of the EPIYA segments contains a single EPIYA tyrosine phosphorylation motif (shown as a black box), which is phosphorylated by kinases such as SFKs and c-Abl.
Host cell molecules that interact with CagA Name of Molecule Binding site on Pathobiological effect of CagA the interaction ASPP2 Domain I Degradation and inactivation of p53 RUNX3 Domain I Degradation and inactivation of RUNX3 Phosphatidylserine Domain II CagA delivery, (PS) (basic patch) Membrane tethering of CagA O1-Integrin Domain II CagA delivery, Stimulation of SFKs and FAK C-terminal Src EPIpYA-A Aberrant activation kinase (CSK) EPIpYA-B of CSK, Inhibition of SFK activity PI3K EPIpYA-B Deregulation of the PI3K-AKT pathway SHP2 EPIpYA-C Deregulation of the EPIpYA-D Ras-ERK pathway, Inhibition of FAK Grb2 EPIYA?
(43) Through complex formation, CagL activates integrin signaling that stimulates Src family kinase (SFK) activity, which in turn phosphorylates delivered CagA.
(48) Membrane-localized CagA then undergoes tyrosine phosphorylation at the Glu-Pro-Ile-Tyr-Ala (EPIYA) tyrosine-phosphorylation motif, present in multiple numbers in the Cterminal polymorphic region (EPIYA-repeat region) of the protein, (49) by SFK members such as c-Src, Yes, Fyn, and/or Lyn, (50)'51) which are expressed in gastric epithelial cells at variable levels, and by c-Abl.