Aberrant methylation of the Wnt antagonist SFRP1
in breast cancer is associated with unfavourable prognosis.
antagonizes canonical Wnt signaling either by interacting with Wnts to prevent them from associating with Fzd receptors or by binding directly to frizzled proteins to form a nonfunctional complex (53).
In the women whose biopsy results did not indicate cancer, methylation of another tumor suppressor gene, called SFRP1
, was more common in milk from the biopsied breast than the other breast.
In women whose biopsy result did not show cancer, methylation of another tumor suppressor gene, SFRP1
, was more common in milk from the biopsied breast than the other one.
The genes, ERa and SFRP1
, are expressed in normal colorectal tissue but silenced by methylation in colon cancer.