Wright and colleagues mapped the distribution of SGLT
2 in human tumors, then measured glucose uptake in fresh tumors using a form of glucose that is specifically transported by SGLTs
The report explains the effect of the growing government approval for new classes of drugs such as SGLT
inhibitors and GLP-1 agonists as the prime growth drivers for the Asia Pacific type 2 diabetes therapeutics market.
Phloridzin (phloretin-2'-0-glucoside), a non-selective SGLTs
inhibitor has been shown to protect against the deleterious effects of diabetic cardiomyopathy in db/db mice (Cai et al.
Major pharmacologic approaches include insulin, PPAR agonists, DPP-IV inhibitors, GLP-1 analogs and SGLT
Pharmacologic approaches include SGLT
inhibitors, glucokinase activators, 11beta-HSD1 inhibitors and many others.
2 Inhibitor Q & A How do the new SGLT
The renal SGLT
system plays a major role in overall glucose balance in the body.