SGLTSodium-Glucose Linked Transporter
SGLTSave the Golden Lion Tamarin (conservation program)
SGLTSpace-Ground Link Terminal
SGLTSodium-Glucose Luminal Cotransporter (physiology)
References in periodicals archive ?
Wright and colleagues mapped the distribution of SGLT2 in human tumors, then measured glucose uptake in fresh tumors using a form of glucose that is specifically transported by SGLTs.
The report explains the effect of the growing government approval for new classes of drugs such as SGLT inhibitors and GLP-1 agonists as the prime growth drivers for the Asia Pacific type 2 diabetes therapeutics market.
Phloridzin (phloretin-2'-0-glucoside), a non-selective SGLTs inhibitor has been shown to protect against the deleterious effects of diabetic cardiomyopathy in db/db mice (Cai et al.
The SGLT proteins use the energy from this downhill sodium ion gradient created by the ATPase pump to transport glucose across the apical membrane against an uphill glucose gradient.
2] (104,105) Abbreviations: AE, adverse event; ALB, albiglutide; ALO, alogliptin; BID, twice daily; CANA, canagliflozin; CYP, cytochrome P; DAPA, dapagliflozin; DDI, drug-drug interaction; DPP, dipeptidyl peptidase; DUL, dulaglutide; EMPA, empagliflozin; ESRD, end-stage renal disease; eGFR, estimated glomerular filtration rate; EXEN, exenatide; GI, gastrointestinal; GLP-1 RA, glucagon-like peptide 1 receptor agonist; GLY, glyburide; HF, heart failure; LINA, linagliptin; LIR, liraglutide; MOA, mechanism of action; MET, metformin; QW, once weekly; RI, renal impairment; SAXA, saxagliptin; SGLT, sodium-glucose cotransporter; SITA, sitagliptin; SU, sulfonylurea; T2DM, type 2 diabetes mellitus; TZD, thiazolidinedione.
Major pharmacologic approaches include insulin, PPAR agonists, DPP-IV inhibitors, GLP-1 analogs and SGLT inhibitors.
Pharmacologic approaches include SGLT inhibitors, glucokinase activators, 11beta-HSD1 inhibitors and many others.
Fast acting Insulins, Long acting Insulins, Intermediate and Fast acting Insulins, Intermediate acting Insulins, Biguanides, Glitazone and Biguanide combinations, Biguanide and Sulphonylurea combinations, Glinides, Sulphonylureas, Glitazones, DPP-IV Inhibitors, Glp-1 Agonists, Alpha-Glucosidase Inhibitors, DPP-IV Inhibitor and Biguanide combinations, Glitazone and Sulphonylurea combinations, SGLT Inhibitors, SGLT Inhibitor and Biguanide combinations, PTP1B Inhibitors and all other Oral Antidiabetic classes.
The renal SGLT system plays a major role in overall glucose balance in the body.