SHGBSex Hormone-Binding Globulin
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Peripheral markers of thyroid hormone like SHGB and angiotensin converting enzyme (ACE) are often elevated in TSHomas, however, they are usually normal in cases with THR (1).
The team, led by Dr Irwin Goldstein, measured SHGB levels in the women over a year and found they were seven times as high in pill-users as in women who had never taken them.
A two-fold mechanism of action has been suggested: (i) interaction with blood levels of free (active) steroid hormones by displacing them from their SHBG binding sites and (ii) prevention of the interaction of prostate receptors with SHGB (Schmidt, 1983).
But now scientists in Massachusetts, America, have found that women likely to develop pre-eclampsia have a reduced blood level of the hormone SHGB in the first 12 weeks of pregnancy.