SHP2Src Homology Phosphatase 2
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The finding is also encouraging because SHP2 is a member of a large family of enzymes called protein tyrosine phosphotases (PTPs), which are important in the signaling processes that control all essential cellular functions.
One of the key steps in lymphomagenesis appears to be the interaction of the SHP2 (PTPN11)/GRB2 complex with ALK through SHC to enhance phosphorylation of ERK1/2 via SRC and son of sevenless.
VioQuest has two targeted cancer therapy compounds in Phase I/IIa clinical trials, VQD-002, a novel inhibitor of activated Akt, which is found disproportionately in resistant and aggressive solid and hematologic tumors and Lenocta (TM), an inhibitor of specific protein tyrosine phosphatases (PTPases) SHP1 and SHP2.