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SIGLECSialic Acid-Binding Immunoglobulin-Like Lectin
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References in periodicals archive ?
If that hypothesis is correct, adding another Siglec gene to mice should make the rodents live longer.
Longevity by the numbers How long a species lives depends upon the number of "Siglec" genes it carries, a new study suggests.
The genes produce proteins known as CD33-related Siglecs.
These Siglecs are proteins that recognize different versions of sialic acid, sugars that stud cells in the body.
When the researchers genetically engineered mice to lack one of the Siglecs, encoded by a gene called Siglec-E, those mice died younger than mice that had all five intact genes.
The finding suggests that Siglecs protect against oxidative damage, but exactly how they do it isn't known.
The study provides preliminary but intriguing data that Siglecs play a role in keeping inflammation and oxidative damage--and thus aging--at bay.
Genomic organization of the siglec gene locus on chromosome 19813.4 and cloning of two new siglec pseudogenes.
Varki, "Siglecs and their roles in the immune system," Nature Reviews Immunology, vol.
Prieto et al., "Splenic CD163+ macrophages as targets of porcine reproductive and respiratory virus: role of Siglecs," Veterinary Microbiology, vol.
Schwarz et al., "Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer," Proceedings of the National Academy of Sciences of the United States of America, vol.