SKP2S-Phase Kinase-Associated Protein 2
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Previous studies have developed a small molecule inhibitor of Skp2, named SKPin C1 (9).
To establish molecular circuits of cell cycle control for mathematical modeling, we used QIAGEN's Ingenuity[R] Pathway Analysis (IPA[R], QIAGEN Redwood City, https://www to generate a 14-protein network, which involve key proteins in regulating cell cycle and with extremely high relevance in human cancers including cyclin proteins (CCND1, CCNE1, and CCN), CDKs (CDK1,2,4, and 6), SKP2, CDKN1B, p53, and CDH1.
Effect of Intermittent High Glucose on Expression of CyclinD1, Skp2, p21, and p27 Protein Levels in INS-1 Cells.
Zhang et al., "FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2," Journal of Clinical Investigation, vol.
Number Gene symbol Gene annotation 1 MYC v-myc myelocytomatosis viral oncogene homolog (avian) 2 P15 Cyclin-dependent kinase inhibitor 2B 3 CDK4/6 Cyclin-dependent kinase 4 4 CCND1 Cyclin D1 5 MAX MYC associated factor X 6 CKS1 CDC28 protein kinase regulatory subunit 1B 7 SKP2 S-phase kinase-associated protein 2 (p45) 8 CCNE1 Cyclin E1 9 E2F3 E2F transcription factor 3 TABLE 5: Results on inference of real networks, where the accuracy is shown for each case.
"MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3," PLoS One.
A Fatty Acid Synthase Blockade Induces Tumor Cell-cycle Arrest by Down-regulating Skp2. J Biol Chem.
Otro de los problemas cruciales sobre los que no se pudo profundizar, fue sobre el impacto que tiene el ejercicio fisico en los marcadores tumorales asociados al cancer de mama [ErbB-2, P53 FOSFOPROTEINA, proliferacion celular (Ki67), BRCA1, PCNA, receptores hormonales ER/PR, Bcl-2, DDB2 proteina, P27 PROTEINA, SKP2, IGF1, IGF2, IGFBP1-3, Estradiol] y de esta forma plantear las posibles vias y mecanismos biologicos de accion.
Laboratory experiments have shown that switching off a gene called Skp2 triggers ageing, or "senescence", in cancer cells.