SKZLStichting Kwaliteitsbewaking Ziekenhuis Laboratoria (Dutch: Hospital Laboratories Quality Foundation)
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To date, the SKZL includes in the EQA surveys six lyophilized, sucrose-protected control materials (PRM 2 and/or PRM 3 materials as defined in Table 1) and two commercial control materials for assessing the quality of lipid measurement in The Netherlands.
All measurements and recalculated results were reported to the SKZL for central data analysis.
Again, all raw data and/or recalculated data were reported to the SKZL for central data analysis.
Hence, it was decided to scale up the production of the PRM 15 arm, the original NCCLS C37-A material, for field evaluation and to perform a national commutability study and two national harmonization studies using PRM 2, a prototype of the lyophilized, sucrose-containing survey materials of the SKZL, and PRM 3, a prototype of the regularly frozen survey materials of the SKZL, for comparison.
To this end, the regular SKZL survey facilities were used.
To follow up the national lipid harmonization projects presented in this study and to further improve accuracy of lipid and apolipoprotein measurements in The Netherlands, the SKZL and the Lipid Task Force of Calibration 2000 recently appealed to the regional clinical chemistry societies to motivate their professionals to further diminish lipid and lipoprotein method biases by periodically (e.g., yearly) assessing their bias using the NCCLS C37-A-type material.
The HDL-chol values assigned by the LRL Rotterdam to the SKZL CRMs are presented in Table 2.
Whereas the precision of HDL-chol analyses is monitored periodically in the SKZL, the Dutch proficiency testing program provided by the Dutch National External Quality Assurance Society, accuracy can only be checked relative to the scores of colleagues (grand mean).
(1) Nonstandard abbreviations: DCCT, Diabetes Control and Complications Trial; glyHb, glycohemoglobin; IDDM, insulin-dependent diabetes mellitus; SKZL, Stichting Kwaliteitsbewaking klinisch chemische Ziekenhuis Laboratoria.
SKZL calibrator, % glyHb Calibration curve (b) Low Medium High Slope Intercept, % glyHb Assigned value 4.6 7.7 10.8 Mean measured value 5.56 7.65 9.65 0.66 2.54 SD 0.12 0.21 0.19 0.02 0.17 CV, % 2.2 2.8 2.0 3.7 6.8 [r.sup.2] (c) 0.029 0.007 0.009 0.0003 0.004 (a) From 23 determinations over a 3-month period.