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In developing nations, these justifications were coupled with argument that the SLPEs facilitated economic independence and planned development.
The state no longer had the financial resources either to offset the losses of SLPEs or to provide the capital necessary for their development.
SLPE Regulates Genes Involved in the Cell Cycle, Cell Proliferation, and Apoptosis.
The aims of this study were to determine whether SLPE has anticancer activity in vivo and to define its mechanism of action.
We used water extraction, the most commonly used approach, to identify four major components, namely, ferulic acid, ligustrazine, senkyunolide I, and parietic acid in SLPE (Figure 1(b)).
The NF-[kappa]B p65 level was significantly lower after treatment with SLPE than that in the control.
We found increased levels of cyclin D1 and p16 after treatment with SLPE by western blotting and immunohistochemistry, indicating that SLPE might arrest the cell cycle, thereby inducing apoptosis.
In light of our results, we conclude that SLPE inhibited the NF-[kappa]B p65 signaling pathway.
(b) Tumor weight (g) in BALB/C mice after 17 days of treatment with 5-Fu, SLPE, or 5-Fu + SLPE.
Caption: Figure 3: (a) (A) NF-[kappa]B p65, cyclin D1, and p16 expression in tumors after treatment of BALB/C mice with 5-Fu, SLPE, or 5-Fu and SLPE by western blotting analysis.
Compared to control (G1), cyclin D1 expression decreased after treatment with 5-Fu (25 mg/kg G2), SLPE (0.1 mg/kg, G3), or 5-Fu and SLPE (G4).
Compared to the control (G1), p16 expression increased after treatment with 5-Fu (25 mg/kg, G2), SLPE (0.1 mg/kg, G3), or 5- Fu and SLPE (G4).
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