Rate the interviews according to the established SLPI criteria and dimensions (the Rater component)
Meet with the other team members and reach consensus on candidate scores on the established SLPI criteria and dimensions
By assessing the cross-validation error rate for pancreatic cancer, CA 19-9, YKL-40, CA-125, CEA, osteopontin, ErbB2, Adam 8, SLPI
, VEGF, IGF-2, and CTGF showed promise combined into a panel assay.
The two types of protease inhibitors produced in Clara cells, SLPI
(16-18) and the elastase-specific inhibitor elafin (17,18), have an antiinflammatory effect.
In naturally occurring concentrations, only SLPI seemed to protect white blood cells from HIV infection.
Next, the team showed that SLPI works by interacting with white cells, not HIV.
The next step is to identify the SLPI receptor and determine the role it plays in HIV entry into host cells," McNeely says.
In experiments with hamsters, other researchers have shown that SLPI
can prevent inflammatory damage to lung tissue.
, or secretory leukocyte protease inhibitor, is a recombinant protein that inhibits several inflammatory proteases.
During the quarter, Amgen senior management decided to seek a development and commercialization partner for SPI, recombinant Serine Protease Inhibitor (also known as SLPI
, Secretory Leucocyte Protease Inhibitor), which is in preclinical development for the treatment of asthma.