SMEZ

AcronymDefinition
SMEZStreptococcal Mitogenic Exotoxin Z
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References in periodicals archive ?
The presence of speA, speB, speC, speG and smeZ genes were tested by polymerase chain reaction (PCR) as described before [7-10].
The distribution of speA, speC, speG and smeZ genes in carriers and patients is shown in Table 2.
The presence of speA (11/14, p=0.005) and smeZ (8/14, p=0.004) was significantly higher in emm1 and the presence of speG was significantly lower in emm4 (p=0.005) when compared to the other emm types.
When the profiles were adapted to the genes that were investigated in our study, ++-+-, -+++-, -+-+- profiles (defined by the presence/absence of speA, speB, speC, speG and smeZ in order) were among the most common profiles in corcordance with Schmitz's data [7].
SMEZ, which began trading on the NYSE Arca on June 5, 2014, seeks to provide investors with access to small companies across the euro zone.
The roles of GAS in the rapid progression of disease were highlighted by the abundance of GAS found the lungs, extensive and severe pulmonary damage, and virulence factor profiles of the isolates, all of which included sda1, smeZ, speA, speB, speG, speJ, and emm-1 genes (4,5).
All of the GAS isolates harbored speB, and almost all possessed speC, speF, speG, smeZ, and ssa.
(%) patients, by age emm type [less than or >5 y, p or SAg equal to] 5 y, n = 246 n = 401 value emm type 12 203 (82.5) 291 (72.6) 0.004# 1 34 (13.8) 77 (19.2) 0.078 Other 9 (3.7) 33 (8.2) 0.022# ([dagger]) SAg SpeA 47 (19.1) 96 (23.9) 0.15 SpeB 246 (100.0) 401 (100.0) NA SpeC 243 (98.8) 400 (99.8) 0.156 ([double dagger]) SpeF 245 (99.6) 400 (99.8) 1 ([double dagger]) SpeG 246 (100.0) 399 (99.5) 0.528 ([double dagger]) SpeH 192 (78.0) 301 (75.1) 0.387 SpeI 190 (77.2) 302 (75.3) 0.578 SpeJ 47 (19.1) 92 (22.9) 0.249 SpeK 1 (0.4) 3 (0.7) 1 ([double dagger]) SpeL 2 (0.8) 5 (1.2) 0.715 ([double dagger]) SpeM 5 (2.0) 9 (2.2) 0.857 SmeZ 245 (99.6) 400 (99.8) 1 ([double dagger]) Ssa 241 (98.0) 391 (97.5) 0.705 No.
Since these reports, several novel streptococcal SAgs have been identified, including streptococcal mitogenic exotoxin Z (SMEZ; 30), SMEZ-2, SPE-G, SPE-H (31), SPE-J, and SPE-I (32), all possessing typical SAg features and are highly mitogenic on human T cells.
All known streptococcal SAgs (with the exception of SMEZ, SPE-G, and SPE-J) are localized on mobile DNA elements (34).
All recombinant toxins were used at subsaturating concentrations, which were 0.05 ng/mL (SMEZ-2), 0.1 ng/mL (all other SMEZ variants, SPE-C, SPE-I, SPE-J, streptococcal superantigen [SSA]), 1 ng/mL (SPE-G), 2 ng/mL (SPE-A), and 10 ng/mL (SPE-H).
The purified DNA was resuspended in 50 [micro]L of Tris-EDTA buffer and used for polymerase chain reaction (PCR) with specific primers for the sped, speC, speG speH, speI, speJ, ssa, and smez genes as described previously (31 33).