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SMMHCSmooth-Muscle Myosin Heavy-Chain
SMMHCSuperstition Mountain Mental Health Center, Inc. (est. 1986; Apache Junction, AZ)
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Caption: Figure 6: Smooth muscle myosin heavy chain (SMMHC) highlights the myoepithelial cells around the lobules.
(60) Myoepithelial carcinomas frequently express vimentin (100%), calponin (75%-100%), S100 (82%-100%), CK AE1/3 (90%-100%), 34[beta]E12 (92%), CAM 5.2 (89%), pancytokeratin (74%), and EMA (21%-100%); less frequently express caldesmon (50%), SMA (35%-50%), MSA (31%), GAFP (31%-50%), SMMHC (30%), p63 (28%), EMA (27%), and Ki-67 (labeling index, 4%-65%); occasionally express CD117 (6%) and desmin (10%); and do not express CEA.
The tumor expresses CK7, CK14, CEA, SMA, MSA, SMMHC, calponin, p63, S100, vimentin, Wilms tumor 1 (WT1), and GFAP.
Its immunoreactivity was comparable to p63 and SMMHC. (36)
c, Smooth muscle myosin heavy chain (SMMHC) staining highlights basal cells in continuous cytoplasmic pattern.
(11) However, compared to SMMHC, it is a less sensitive and specific marker of MECs and shows more heterogeneity in the immunostaining pattern.
In our practice, we use a panel of 3 single stains: SMMHC, calponin, and p63.
Overall, CD10 is less sensitive than MSA, SMMHC, and MSA in identifying MECs in the neoplastic setting.
The sensitivities of CK5/6, CK14, and CK17 for MECs are, in our experience, comparable to those of SMA, MSA, p63, and SMMHC, whereas 34[beta]E12 (which recognizes CK1, CK5, CK10, and CK14) exhibits considerably lower sensitivity.