SN-VTA

AcronymDefinition
SN-VTASubstantia Nigra and Ventral Tegmental Area
References in periodicals archive ?
In SN-VTA, the increased Nrf2, HO-1, and NQO-1 mRNAs were detected in PTX.in-SE and PTX.ip-SE rats (P < 0.05), compared with SE-cl rats, except NQO-1 mRNA in PTX.ipSE rats 24hrs following Pc injection (P = 0.234).
The protein levels of Nrf2, HO-1, and NQO-1 extracted from sN-VTA and Hip were detected by Western blot.
We analyzed the ratio of GSH/GSSG by measuring GSH and GSSG in SN-VTA and Hip.
The transient activation of Nrf2-ARE pathway might be a response to the oxidative stress caused by SE [55], but SE-induced Nrf2 activation was not enough to protect neurons from oxidative damage, which underlay the defects in mesodopaminergic system, as well as the elevated LPO and MDA in SN-VTA and Hip of SE rats in the present studies.
Compared with SE rats, the significant elevation of Nrf2, HO-1, and NQO-1 in SN-VTA and Nrf2 in Hip of intranasal Ptx-pretreated SE rats 24 hrs following Pc injection indicated the region-specific involvement of Nrf2-ARE pathway.
Caption: Figure 4: Effects of intranasal and intraperitoneal Ptx pretreatment on oxidative damage in SN-VTA and Hip of SE rats induced by Li-Pc 24 hrs and 7 days after Pc injection.
Caption: Figure 5: Effects of intranasal and intraperitoneal Ptx pretreatment on Nrf2 in SN-VTA of SE rats induced by Li-Pc 24 hrs and 7 days after Pc injection.
Caption: Figure 6: Effects of intranasal and intraperitoneal Ptx pretreatment on HO-1 in SN-VTA of SE rats induced by Li-Pc 24hrs and 7 days after Pc injection.