Triptans, which are 5-hydroxytryptamine receptor agonists used to treat migraine; and SSRIs and SNRIs
, used to treat depression and other mood disorders, are serotonergic drugs.
In addition to RENAISSANCE 2 and RENAISSANCE 3 (previously reported), the RENAISSANCE Program includes two fixed dose studies (RENAISSANCE 4 and RENAISSANCE 5) designed to evaluate the efficacy and tolerability of TC-5214 as an adjunct treatment to SSRI/SNRI
therapy and RENAISSANCE 7, a long-term study designed primarily to evaluate safety in which patients receive a fixed dose of TC-5214 or placebo, plus a baseline SSRI or SNRI
, for one year.
There is great need for an effective medication with a favorable side effect profile for the millions of patients who do not respond fully to or are not compliant with current antidepressant treatments, such as SSRIs or SNRIs
," said the principal investigator of the TRIADE study Maurizio Fava, M.
Abbreviations: BPH = benign prostatic hypertrophy, CPG = clinical practice guideline, DOD = Department of Defense, FY = fiscal year, ICD-9 = International Classification of Diseases 9th Revision, PTSD = posttraumatic stress disorder, SSRI/ SNRI
= serotonin reuptake inhibitor/serotonin norepinephrine reuptake inhibitor, VA = Department of Veterans Affairs, VHA = Veterans Health Administration.
Bupropion is clearly better than SSRIs and SNRIs
for MDD with antidepressant related sexual dysfunction, nicotine dependence, or ADHD," he said.
Shire plc announces top-line results from two pivotal Phase 3 investigational studies evaluating the efficacy and safety of VyvanseA (lisdexamfetamine dimesylate) Capsules (CII) versus placebo as an adjunctive treatment for major depressive disorder (MDD) in adults who inadequately responded to antidepressant monotherapy with a SSRI or SNRI
The benzodiazepines are best reserved for short-term use (2-4 weeks) in the early phase of treatment of GAD with an SSRI or SNRI
to provide some symptomatic relief until the antidepressant has begun to work, to treat insomnia if it is a predominant symptom, and to protect against occasional early worsening of anxiety seen with the initiation of therapy.
For managing vasomotor symptoms such as hot flashes, the guideline recommends that - because hormonal therapy is generally contraindicated in women with hormone-positive breast cancer - an SSRI, an SNRI
(serotonin norepinephrine reuptake inhibitor), or gabapentin be used instead.
Table: FDA approved SSRI and SNRI
options for anxiety disorders Medication Panic PTSD GAD OCD SAD Fluoxetine (SSRI) [check] [check] Paroxetine (SSRI) [check] [check] [check] [check] [check] Sertraline (SSRI) [check] [check] [check] Escitalopram (SSRI) [check] Venlafaxine ER (SNRI
) [check] [check] [check] Duloxetine (SNRI
) [check] Fluvoxamine GR (SSRI) [check] [check] Key: PTSD - posttraumatic stress disorder; GAD- generalized anxiety disorder; OCD - obsessive compulsive disorder; SAD - social anxiety disorder
While SSRI and SNRI
medications can provide much-needed relief to some patients, clinical trials have shown that 40% to 50% of depressed patients are unresponsive to first-time treatment.
Even after searching for all published and unpublished studies--worldwide--and despite the many claims made in favour of antidepressant use, they failed to find any scientific evidence that either pregnant women or their babies benefit from use of SSRI/ SNRI
4 shows SNRI
results of TDICA with different initial value, from which it is confirmed that better initialization benefits better performance.