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rRNA, tRNAs, snoRNAs and snRNAs (xfam.org), the remained reads with the length of 20-21 nt were then used to validate potentially cleaved targets by the CleaveLand tool (Addo-Quaye et al., 2009; Zhou et al., 2012).
Statistical analysis: The relative expression levels of the miR-1 miR-133 HDAC4 and SRF were normalized with internal control (U6 snRNA) expression level which was calculated using the 2_ Ct method (Livak and Schmittgen et al.
The Binding of the U1 snRNA. We studied the ungapped base-pairing between the U1 snRNA sequence ACTTAC (NCBI GenBank accession code NR004430), conserved in Mouse and Human, and the last three nucleotides of the exons plus the corresponding 5'ss hexanucleotide.
BLASTN search was performed against Rfam 11.0 (http://rfam.sanger.ac.uk/) to distinguish between miRNA and other small RNA families such as rRNA, snRNA, and tRNA.
TCIRGl-dependent recessive osteopetrosis: mutation analysis, functional identification of the splicing defects, and in vitro rescue by U1 snRNA. Hum Mutat 2004; 24 : 225-35.
In addition, the modified U7 snRNA (U7.623) was also searched and used for further study.
"The U1 Adaptor platform expands on early technologies that used 5'-end-mutated U1 snRNA. The U1 Adaptor is an oligonucleotide version of this older method and instead targets the 3' end processing step.
Inhibition of fibrillin 1 expression using U1 snRNA as a vehicle for the presentation of anti-sense targeting sequence.
(14) Third, the metal-binding domain of II introns (domain V) can functionally substitute for the metal-binding portion of one of the RNA components (the U6atac snRNA stem-loop) of the spliceosome.
Research biologists from around the world examine the biochemical aspects of the silencing machinery; the methods of RNA silencing in non- mammalian organisms; how to design, prepare, and use RNAs to silence gene expression; how RNA interference technology can be used to fine-tune the regulation of some gene expression by targeting specific isoforms of a given gene; methods for studying and using microRNAs; and an approach to down-regulating gene expression based on U1 snRNA, which acts only in the nucleus.
The spliceosome, a complex which contains small nuclear RNA (snRNA) and small nuclear ribonucleoprotiens (snRNPs), is where the splicing of pre-messenger RNA (pre-mRNA) molecules occurs.
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- SNR bandwidth product
- SnRNP assembly defective 1 homolog
- snRNP core Sm-like protein Sm-x5