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SOCS2Suppressor of Cytokine Signal 2
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References in periodicals archive ?
Spence et al., "Regulation of [Foxp3.sup.+] inducible regulatory T cell stability by SOCS2," The Journal of Immunology, vol.
For example, CIS, SOCS1, SOCS2, and SOCS3 have relatively short (50-80 residues) N-terminal regions, whereas SOCS4, SOCS5, SOCS6 and SOCS7 have longer N-terminal regions of up to 380 residues [22, 25, 26].
Secondly, SOCS2 has been shown to possess the ability to antagonise other SOCS family members [43].
In general, SOCS proteins such as CIS and SOCS2 can function by blocking access to phosphotyrosine residues and targeting proteins for ubiquitination and proteasomal degradation.
Therefore, SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which OSA's activated proinflammatory cytokines alter both GH/IGF-1 signaling and cellular function.
Ahmed, "Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling," Pediatric Nephrology, vol.
Production of IL-6 and IL-12p40 Human dendritic Production of cells IL-12p70, IL- 1[beta], and IFN-[gamma] Human blood Secretion of mononuclear cells TNF-[alpha], IL-1[alpha], IL-1[beta], IL-4, IL-6, IL-10, and GM-CSF Human homozygotic Production of macrophages TNF-[alpha], (3020insC mutation) IL-1[beta], and IL-10 Murine and human Activation of CD8 T cells NF-[kappa]B, p38 and JNK Secretion of TNF-[alpha], IL-2, and, IFN-[gamma] Induction of cellular proliferation and expansion Monocyte derived- Secretion of dendritic cells IL-1[beta] and IL-23; expression of SOCS2 TABLE 3: Analysis of the collaborative action of TLRs and NRLs in response to pathogenic bacteria.
WB analysis was performed on protein lysates of HaCaT keratinocyte clones overexpressing SOCS1, SOCS2, or SOCS3, stimulated with IFN- [gamma] (a) or IL-22 (b) or left untreated.
(a) microRNA miR-516-5p miR-517 * miR-526a miR-525 miR-520a * Number of 349 179 212 340 352 predicted target genes Unique target genes Shared with miR-525 CCR2 FAS BCAP29 TOX ACVR2B CD109 IL6ST CD24 AHSA2 CD1A IL9R CD302 ATRN DNAJC25 IRAK3 CFLAR CD2 FLT1 LILRA2 DNAJC21 CD300LB IL17RE MTDH HSP90AA1 CD46 IRAK1 PAPPA IGFBP1 CD93 LILRB5 TLR2 HSF5 PDCD6IP TNFRSF19 IGF1R SOCS2 TNFSF15 IL10RA TRAF6 MMD2 PPARA TLR7 VSIG4 All the targets were predicted by a bioinformatics tool MirTarget2 using miRDB online database.
placental exosomes isolated from maternal peripheral circulation suppressed T cell expression of CD3-zeta and JAK3, while inducing SOCS2. The level of CD3-zeta on T [CD8.sup.+] cells was inhibited 1.43-fold more than in T [CD4.sup.+] cells [18].
Mapping, tissue distribution and polymorphism study of the porcine SOCS2 and SOCS3 genes.