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Related to SOD1: SOD2, SOD3, G93A
SOD1superoxide dismutase 1 (gene)
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References in periodicals archive ?
This orphan drug designation represents an important recognition by the FDA of APB-102's potential to treat SOD1 ALS, a rare genetic form of ALS, said John Reilly, CEO and Co-Founder of Apic Bio.
(30) Our study suggests antioxidant activity of AFED and interference of SOD1 and NRF2 expression in signaling pathways.
The decreased intracellular ROS level upon EGCG treatment may contribute to its direct radical scavenging activity or to the EGCG-induced increase of antioxidative enzyme activity In the present study, it was found that the mRNA levels of SOD1, CAT, and GPX4 were significantly upregulated in EGCG treatment groups.
with of miR-146a 2010 (37) inflammation expression ALS SOD1 and others An artificial Stoica et al.
Scientists found that ebselen, a drug which was discovered in the 1980s and has been investigated as a potential treatment for a variety of nervous system disorders, can effectively restore several important steps in the SOD1 assembly process including folding, dimerisation, and zinc binding.
Danish biotechnology company Orphazyme A/S (CPH:ORPHA.CO) announced on Wednesday that a manuscript reporting the Phase II trial results for arimoclomol in patients with SOD1 Amyotrophic Lateral Sclerosis (ALS) was published in the peer-reviewed clinical journal Neurology.
The accumulating evidence suggests that a mutant part of the antioxidant enzyme superoxide dismutase 1 gene (SOD1) plays a key role in developing FALS and provides insight regarding the pathway causing sporadic ALS (SALS) [8-10].
Here, we report that upregulation of EZH2 accompanies SOD1 downregulation in the lung during TAC-induced PAH.
Patients with mutations in the SOD1 gene might in future profit from oligonucleotide strategy, but the clinical trials are still ongoing [4, 5].
Once oxidative stress occurs, Nrf2 dissociates from Keap1 and translocates to the nucleus, where it functions as a strong activator of the antioxidant response element (ARE) and regulates protective genes, such as heme oxygenase-1 (HO-1) and superoxide dismutase 1 (SOD1), eventually enhancing cell survival [12].