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SOLVDStudies Of Left Ventricular Dysfunction
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The original SOLVD trials randomized nearly 7,000 Americans, Canadians, and Belgians with congestive heart failure (CHF) or asymptomatic left ventricular dysfunction to enalapril or placebo, then followed them for a mean of 3.
Greenberg B, Quinones MA, Koilpillai C, Limacher M, Shindler D, Benedict C, et al, for the SOLVD Investigators.
Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure: SOLVD Investigators.
The main data backing ACE inhibitors in symptomatic patients come from the treatment arm of the SOLVD trial, and Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS I) (N.
A subset of 241 patients ANP (RIA) 1996 (87) with asymptomatic left ventricular dysfunction were enrolled in the SOLVD Prevention Trial Tsutamoto et al.
The jury appears still to be out, as the controversial ALLHAT results run counter to those of other major trials-including the HOPE and SOLVD trials-which found that ACE inhibitors are superior to diuretics.
ACE inhibitors were demonstrated unequivocally to be lifesaving in patients with heart failure in 1993 with the SOLVD trial.
From the evidence that's accumulating, going back to SAVE [the Survival and Ventricular Enlargement trial], SOLVD [Studies of Left Ventricular Dysfunction], HOPE, and now EUROPA, it would appear that we're dealing with a class effect," said the cardiologist, who wasn't involved in EUROPA.
The SOLVD Investigators: Effects of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure.
Not since the SOLVD registry of patients treated with an ACE inhibitor have researchers evaluated the impact of a particular treatment on such a large population of patients with heart failure, and no program of this magnitude has documented the impact of beta-blockade on morbidity and mortality or change in clinical status in heart failure.