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SOLVDStudies Of Left Ventricular Dysfunction
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[46.] Greenberg B, Quinones MA, Koilpillai C, Limacher M, Shindler D, Benedict C, et al, for the SOLVD Investigators.
A report by the Studies of Left Ventricular Dysfunction (SOLVD) showed that patients with diabetes, when compared to those who did not have diabetes, were admitted more often for congestive heart failure and had a higher rate of all-cause mortality, cardiovascular mortality, and mortality related to pump failure (Shindler et al., 1996).
Treatment with ACE inhibitors improved survival and markedly reduced hospitalizations among all categories of heart failure patients (CONSENSUS Trial Study Group, 1987; SAVE Investigators, 1992; SOLVD Investigators, 1992).
Evidence linking HF and DM also comes from the HF trials (SOLVD, ATLAS and V-HeFT II), in which diabetes was found in 19%-26% of patients as compared to 4%-6% in the general population.
One year-incidence of new onset anemia is 9.6% in SOLVD trial, 16.9% in VaL-HeFT, and 14.2% in COMET trial.
A retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) trial suggested that patients on enalapril were more likely to die if they also took aspirin.
Particularly noteworthy was a retrospective analysis of data from the landmark Studies of Left Ventricular Dysfunction (SOLVD) and second Valsartan Heart Failure Trial (Val-HeFT II).
The concentration on heart failure reflects its prevalence in our wards and clinics, and there is exposition of the 'SOLVD' and other landmark studies.
(7.) Shindler DM, Kostis JB, Yusus S, Quinones MA,Pitt B, Stewart D, et al Diabetes mellitus, a predictor of morbidity and mortality in the Studies of Left Ventricular Dysfunction (SOLVD) Trials and Registry.Am J Cardiol 1996; 77: 1017-20.