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In general, PLP1 gene duplications result in a classical form of PMD, nonsense mutations in either form of SPG2 and connatal form of PMD, and other monoallelic mutations have been related to less circumscribed clinical phenotypes6.
As the phenotype is thought to be less severe than the other forms of PMD, some case series have even considered NS to be another variant of Complicated SPG2 (9).
Generally, optimization algorithms, such as LBFGS, SQP, and SPG2, are designed to find the minimum value of the objective function.
Jiankang and Gai (2001) mentioned the occurrence of smaller values for spg2 and hpg2 to be due to epistatic effects between the major and minor genes.
In patients with PMD or SPG2, the myelin that forms is poorly compacted.
and it uses a backtracking nonmonotone line search similar to the SPG2 method.
 Nonstandard abbreviations: PMD, Pelizaeus-Merzbacher disease; SPG2, spastic paraplegia type 2; PLP1, proteolipid protein 1; MLPA, multiplex ligation-dependent probe amplification; and FISH, fluorescence in situ hybridization.
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