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SPINK1Serine Protease Inhibitor, Kazal Type 1
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Comparison of the amino acid sequences of SPINK1 and epidermal growth factor (EGF) revealed similarity (6), and on the basis of this finding it has been proposed that SPINK1 may function as an autocrine or paracrine growth factor.
Therefore, it is possible that the reported differences between EGF and SPINK1 stimulation arise from their ability to induce different members of the EGF receptor family to form heterodimers.
In this review, we highlight recent evidence indicating that SPINK1 also exerts other functions, i.
The role of SPINK1 in tumor growth has also been confirmed experimentally in tissue culture studies and by studies of tumor xenografts in immune-deficient mice.
has focused attention on the role of SPINK1 and, potentially, its use as a target in the treatment of prostate cancer (3).
SPINK1 may be secreted by the same cell that it stimulates, and thus it can be classified as an autocrine growth factor.
5] Human genes: PRSS1,protease, serine, 1 (trypsin 1); PRSS2,protease, serine, 2 (trypsin 2); PRSS3, protease, serine, 3; SPINK1, serine peptidase inhibitor, Kazal type 1.
Mutations in the PRSS1, SPINK1, and CFTR genes were examined by PCR analysis and then analyzed with denaturing HPLC, according to procedures modified from those described in previous reports (15, 25).
We evaluated the presence of 125G/C, 1001>11>CT, 1540A>G (Met470Val), 2694T>G, and 4521G>A variants in CFTR and the 272C>T polymorphism in SPINK1 by direct sequencing.
The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.
Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland.