[USA], Sep 22 ( ANI ): Turns out, mutations in the tumor suppressor gene SPOP
contribute to cancer by disrupting a process called liquid-liquid phase separation.
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP
) regulate steroid receptor coactivator 3 protein turnover.
Other genes that have emerged as significantly mutated genes in whole-exome sequencing studies of serous endometrial carcinomas are SPOP
, a putative tumor suppressor gene; CDKN1A [cyclin-dependent kinase inhibitor 1A (p21, Cip1)], a bona fide cancer gene; TAF1; HCFC1R1 [host cell factor C1 regulator 1 (XPO1 dependent)]; CTDSPL [CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like]; YIPF3 (Yip1 domain family, member 3); and FAM132A (family with sequence similarity 132, member A) (17, 18).
He deployed to OEF VII with the DSTB NSC, fielding the first 12 SPOPs
introduced into the theater.
As the results suggest, BPOP (columns  and , SPOP
(columns , , and ), LFPR (columns , , and ), and GGDP (columns , , and ) are all positive.
Table 2 Correation Matrix of All Independent Variables SALEPS1 SPOP1 PCNI PD POPG SEAT SALEPS1 1.000 SPOP
0.074 1.000 PCNI 0.602 0.009 1.000 PD 0.207 -0.020 0.444 1.000 POPG 0.034 -0.123 -0.071 -0.046 1.000 SEAT 0.606 -0.009 0.725 -0.035 0.041 1.000
Table II Correlation matrix of all independent variables PCNI SPOP
PD POPG AW SEAT PCNI 1.000 SPOP
0.173 1.000 PD 0.442 0.092 1.000 POPG -0.058 -0.147 -0.042 1.000 AW 0.550 0.320 -0.154 0.116 1.000 SEAT 0.722 0.055 -0.017 0.091 0.592 1.000 The F-test statistics for the effect of the 1988 austerity programme are 3.4932 and 3.2361 respectively.
(155) The most frequently mutated gene was SPOP
(13%), which encodes the substrate-binding subunit of a cullin 3-based E3 ubiquitin ligase.
In their study, the investigators at Weill Cornell Medical College, the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute described how they discovered novel mutations in the SPOP
("S-pop") gene in numerous patient tumours.
We find Redline AN-30 and AN-50 radios, VSAT, SPOP
satellite systems, Coalition Military Nodes, HCLOS, Harris 7800 radio systems, and data packages throughout the Iraq network, in every configuration imaginable.
(RAE607) NEIL BLOMQUIST - SPECTRUM ORGANIC PRODUCTS INC (SPOP