SQSTM1Sequestosome 1
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3) Higher arsenic exposure was associated with decreased methylation levels at a locus of the SQSTM1 gene that has been implicated in a number of diseases, including cancer, obesity, insulin resistance, and neurodegenerative diseases.
We identified four novel methylation loci in PLA2G2C, SQSTM1, SLC4A4, and IGH that were strongly associated with arsenic exposure (p < 1 X [10.
SQSTM1 encodes a protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway.