MUHC, pending the completion of a SQV
/ SIV, is able to commence the enrollment and treatment process of BCG-unresponsive NMIBC patients for the Phase II Study.
The cells were cultured to approximately 80% confluency in DMEM and were treated with LPS (2 [micro]g/mL) plus SQV
at 3 [micro]M or 10 [micro]M with or without the TLR4 inhibitor TAK-242 at 1 [micro]M for 24 h.
Regimens containing saquinavir (SQV
) and amprenavir (APV) were the only ones that did not undergo any modification (Figure 2).
Viral Protease Inhibitors Generic Name Initials Trade Name Manufacturer Indinavir IDV Crixivan Merck Nelfinavir Viracept Agouron Ritonavir RTV Norvir Abbott Saquinavir SQV
is the first-generation HIV protease inhibitor that possesses anti-inflammatory characteristics.
It is always used with lopinavir (LPV) (fixed-dose combination) and saquinavir (SQV
) and is strongly encouraged with other PIs.
HIV/AIDS drugs proposed under the Patent Pool of the UNITAIDS Compound Company Lopinavir (LPV) Abbott Ritonavir (r) Abbott Nevirapine (NVP) Boehringer-Ingelheim Atazanavir (ATV) Bristol Myers Squibb GS-9350 Gilead Elvitegravir (EVG) Gilead Tenofovir (TDF) Gilead Emtricitabine (FTC) Gilead Efavirenz (EFV) Merck Raltegravir (RAL) Merck Vicriviroc Merck (Schering-Plough) Saquinavir (SQV
) Roche Etravirine (ETR) Tibotec / J&J Darunavir (DRV) Tibotec / J&J Rilpivirine Tibotec / J&J Lamivudine (3TC) Viiv (GSK) Abacavir (ABC) Viiv (GSK) Fosamprenavir (FSV) Viiv (GSK) Maraviroc Viiv (Pfizer)
ART DRUGS Category I Stavudine (d4T) * NRTI--thymidine base Zidovudine (ZDV) * Category II Didanosine (ddI) * ([dagger]) NRTI--other Lamivudine (3TC) * Emtricitabine (FTC) Abacavir (ABC) * NtRTI Tenofovir (TDF) ([dagger]) Category III Nevirapine (NVP) * NNRTI Efavirenz (EFV) ([paragraph]) Etravirine (ETR) ([section]) Category IV Ritonavir (RTV) * PI Lopinavir/ritonavir (LPV/RTV) * Saquinavir (SQV
) Indinavir (IDV) ([dagger]) Darunavir (DRV) ([section]) Atazanavir (ATV) ([dagger]) Fosamprenavir (FPV) Category V Raltegravir ([section]) Integrase inhibitors Category VI Maraviroc ([section]) CCR5 inhibitors * Available in paediatric formulations.
* IDV + SQV
combination is antagonistic in vitro and in practice extremely difficult to dose
, Absorption increased Take with a meal: high Invirase, the hard- with food and with fat and high calorie gel formulation) grapefruit juice.
Also known as: Ro 31-8959, saquinavir mesylate, SQV
, SQV-HGC, SQV-SGC
The number of patients with LPV, SQV
, and APV use at any time before genotyping (in the last regimen or prior to last regimen) were 130 (76%), 83 (49%), and 35 (20%), respectively.