Tweaking the components of the cycle again, they engineered cells to keep SREBP
in the ER while allowing SCAP to move to the Golgi on its own.
En la membrana de golgi, la proteasa SP1 se activa y corta SREBP
en el medio de su bucle hidrofilo lumenal.
Technology: Inhibition of SREBP
by Betulin Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques
fatty acid synthase; LXR, liver X receptor; LXRE, liver X receptor response element; MGDG, monogalactosyldiacylglycerol; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium; RXR, retinoid X receptor; SCD, stearoyl-CoA desaturase; SP1, stimulatory protein 1 site; SRE, sterol regulatory element; SREBF, sterol regulatory element binding transcription factor; SREBP
, non-canonical sterol regulatory element binding protein recognition site.
Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP
signaling in Drosophila.
Redox stress leads to sodium potassium ATPase inhibition, inward movement of plasma membrane cholesterol, defective SREBP
sensing, increased cholesterol synthesis and nanoarchaeal/mevalonate pathway bacterial growth .
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP
Our study shows that the SREBP
pathway is a good target for several metabolic diseases," said Bao-Liang Song of the Shanghai Institutes for Biological Sciences.
After that, various transcription factors like E2F, YY1, NF[kappa]B, SREBP
, Smad7, etc.
Effect of SCD and SREBP
genotypes on fatty acid composition in adipose tissue of Japanese Black cattle herds.
PPRE, Attagene cis-PPRE reporter gene assay; PPAR[gamma], Attagene and NCGC trans-PPAR[gamma] reporter gene assay and NovaScreen[R] hPPAR[gamma] direct binding assay; GR, Attagene cis-GRE, trans-GR, and NCGC trans-GR reporter gene assay, and NovaScreen[R] hGR direct binding assay; LXR, Attagene trans-LXR[alpha], trans-LXR[beta] and NCGC trans-LXR[beta] reporter gene assay; LXRE, Attagene cis-LXRE reporter gene assay; C/EBP, Attagene cis-C/EBP reporter gene assay; SREBP
, Attagene cis-SREBP
reporter gene assay; RXR[alpha], Attagene and NCGC trans-RXR[alpha] reporter gene assay.
1038/nature06179), Alnylam scientists and collaborators demonstrated the ability of synthetic siRNAs to silence three distinct hepatocyte-expressed genes -- apolipoprotein B, factor VII, and SREBP
cleavage-activating protein, or "SCAP" -- to levels of greater than 80 percent with both single dose and repeat dose administration of target-specific siRNAs in mice or hamsters.