and Thyroid Hormone Responsive Spot 14 (S14) Are Involved in the Regulation of Bovine Mammary Lipid Synthesis during Diet-Induced Milk Fat Depression and Treatment with CLA.
Over-expressing of phosphatase and tensin homolog (Pten) gene, a well-established upstream negative regulator of mTOR signaling pathway, inhibits the expression of SREBP1
and PPARy in BMECs (Wang et al.
Upregulation of CEBPB, CEBPG, SREBP1
and INSIG1 genes implied that ER stress-mediated lipid synthesis was activated.
SREBPs play a central role in cellular lipogenesis and lipid homeostasis by controlling the synthesis of fatty acids, triacylglycerols, and cholesterol  and comprise three main proteins, termed SREBP-1a, SREBP-1c, and SREBP-2, that are encoded by two genes: SREBP1
We found that steers had higher adipogenic SREBP1