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SREBP1Sterol Regulatory Element Binding Protein 1
SREBP1Sterol Response Element Binding Protein 1 (biological chemistry)
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"In NASH-free individuals, the activities of SREBP1 and SREBP2 are kept under control, which is essential for preventing excessive lipid accumulation in the liver," said Karin.
In the first phase, bone morphogenetic proteins (BMPs) and TAK1 pathways are involved, whereas in the second terminal differentiation phase, other transcription factors such as PPAR[gamma], CCATT enhancer-binding proteins (C/EBP), and SREBP1 take action [47].
TMP Downregulates mRNA Expressions ofInsig, PAQR3, SCAP, and SREBP1 in the Aorta, Liver, and Adipose Tissues.
In addition, 11 significantly enriched transcription factor motifs (PAX5, EGR1, XBP1, SREBP1, OLF1, MZF1, NFY, NFKAPPAB, MYCMAX, NFE2, RP58) were identified.
Insulin (10 [micro]g/mL) as the positive control upregulated GLUT4 gene and downregulated AKT, HSL, PI3KA, and Srebp1 genes compared to the untreated cells in the present study.
MiR-27a was thus identified as targeting RXR[alpha], ABCA1, FASN, SREBP1, SREBP2, peroxisome proliferator-activated receptor [alpha] (PPAR[alpha]), and PPAR[gamma] as well as ApoA1, ApoB100, and ApoE3 [16], all of which are molecules significant for the lipid metabolism and some of which were mentioned above.
Betulinic acid has further been reported to alleviate non-alcoholic fatty liver by inhibiting sterol regulatoryelement-binding protein 1 (SREBP1) via the AMPK-mTOR-SREBP signaling pathway [108].
have shown that human MSC-(hMSC-) derived adipocytes, express mRNA encoding for adipogenic transcription factors (PPAR[gamma]2, C/EBP[alpha], and SREBP1), adipokines (adipsin, leptin, APM1, and angiotensinogen), and lipid-metabolizing agents (aP2 and LPL) by day 12 of differentiation and are thus highly analogous to subcutaneous adipocytes at this time point [13].
Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance.
Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP1) by down-regulation of SREBP-1c mRNA in mouse liver.