An abstract of an open-label prospective study describes the effectiveness of denosumab at different stages of CKD in preventing SREs
at the standard dose [8, 9].
An alternate to counter these issues is Satellite Rainfall Estimates (SRE
Increased bone resorption by osteoclasts releases growth factors and calcium from the bone matrix, which may stimulate the tumor to release cytokines and growth factors, contributing to a vicious cycle of bone destruction that can result in devastating SREs
(Drudge-Coates & Turner, 2013).
Bone metastases in PC patients frequently lead not only to intractable pain, but also to burdensome complications known collectively as skeletal-related events (SREs
Many patients with bone metastases will experience skeletal related-events (SREs
) such as severe bone pain, pathologic fractures, or bone instability.
A wide range of RCM outputs, using different SRES
emission scenarios and GCMs presented in the BACC book, indicate a substantial warming for the Baltic Sea region.
Hence, combining the scenarios capturing the projected per capita GDP growth and population growth, the SRES
scenarios and the GCM climate models, results in 15 potential future pathways that encompass a wide range of plausible outcomes in terms of projected yields.
XGEVA was approved by the FDA for the prevention of skeletal-related events (SREs
) in patients with bone metastases from solid tumors in 2010.
While most patients are clinically asymptomatic, those with symptoms may manifest with either pain or as skeletal-related events (SREs