Appearance of external genitalia is normal in 46 XX SRY
positive males and difficult to identify before puberty because of lack of any significant clinical indication except undescended small testis.
It should not be forgotten that mutations in DMRT genes as well as in SRY
, SOX9 and DAX1 may lead to 46,XY ovotesticular DSD.
Primers for GAPDH, SRY
, DYS14, TTC3, RPL17, and hydroxy-delta-5-steroid dehydrogenase and 3 beta- and steroid delta-isomerase 2C (HSDB) are presented in Table 1 [22-26].
Benedetti et al., "A naturally occurring deletion in the SRY
promoter region affecting the Sp1 binding site is associated with sex reversal," Journal of Endocrinological Investigation, vol.
High conservation of SRY
gene in Buffalo compared to other Bovids.
Despite this, SRY
gene was present in 100% of the blood and lung samples from females which received ADSC-Y (group 2) or BMNC-Y (group 3), as proven by visualization of the internal fragment (110bp) by electrophoretic analysis after the PCR second-step (Figure 1D).
Primer and probe sequences for amplification and detection of the X chromosome-specific (PLP) and Y chromosome-specific (SRY
) regions were as previously reported (Parati et al., 2006) (Table 1).
Ortenberg and colleagues[sup.4] found somatic mosaicism caused by an SRY
gene in all individuals studied.
For this study, Ward and her colleagues used transgenic male mice with only two Y genes, Sry
In 90% of cases it is due to translocation of SRY
gene either to X chromosome or some autosome;
Banerjee, 49, whose book about her dramatic escape from the Taliban was made into a Bollywood film, was dragged out of her husband's house by masked gunmen in the Sry
Kala area of Sharan, and shot dead on Sept.