The inclusion criteria consisted of several parameters: (1) SSHL >30 dB affecting >3 consecutive frequencies of pure-tone thresholds within 72 h; (2) both ears were affected either concurrently (the second ear being affected within 3 days of the first ear) or sequentially (the second ear being affected >3 days after the first ear); or (3) no identifiable causes.
In this study, the inclusion criteria of SSHL were based on American clinical practice  instead of Chinese guidelines  in order to facilitate direct comparison with more studies in this area.
There were a number of drawbacks in the present study, which are as follows: (1) we adopted single baseline blood sampling instead of serial sampling; the latter might potentially yield a more reliable and better analytical time point; (2) the inherent defects of a retrospective and single-center study; (3) the study sample included exclusively hospitalized SSHL patients; thus the selection of patients was limited and the findings might not be extrapolated to the general population; (4) although many variables have been taken into consideration, we cannot rule out the possibility that unmeasured factors might contribute to the differences across groups.
One study showed associations between SSHL and smoking, elevated fibrinogen, and with the GP 1 a C807T polymorphism--all factors predisposing to coronary disease.
However, Menibre's sudden onset and timescale of symptoms, and their propensity to recur, are more similar to TAD's features than to those of SSHL.
The arbitrary definition of SSHL excludes patients with symptoms of TAD.
People with SSHL often experience dizziness or a ringing in their ears (tinnitus), or both.
Although a good to excellent recovery is likely, 15 percent of those with SSHL experience a hearing loss that gets worse over time.
Approximately 4,000 new cases of SSHL occur each year in the United States.
Only 10 to 15 percent of patients with SSHL know what caused their loss.
People who experience SSHL should see a physician immediately.
Management of SSHL
include a history and review of symptoms, otologic and neuro-otologic examination, audiological testing and laboratory studies.