6 million recent singleton births in five Nordic countries, showed an association between SSRI
use and both stillbirth and 1-year mortality.
In response to this striking finding, the Food and Drug Administration issued a public health advisory in July 2006 and SSRI
labels were subsequently changed to include information about what the FDA referred to as the "potential risk" for PPHN.
Physicians need to be aware of the serious adverse reactions associated with SSRI
In the 29 months after experiencing a heart attack, depressed patients who happened to be taking SSRIs
displayed only 57 percent as many bad outcomes--new heart attacks and deaths from cardiac cause--as did depressed heart attack survivors who weren't taking SSRIs
Patients were randomized to receive one of three treatments: (1) Deplin([R])(L-methylfolate 15mg) in addition to an antidepressant for 60 days; (2) placebo in addition to a SSRI
for 30 days followed by Deplin([R])15 mg.
79 percent) of mothers had filled a prescription for an SSRI
Since then, there have been conflicting findings from new studies evaluating this potential risk, making it unclear whether use of SSRIs
during pregnancy can cause persistent pulmonary hypertension," the FDA said in a press statement.
In still another study using such data, published online in Archives of General Psychiatry in July investigators from Kaiser Permanente Northern California reported an association between an increased risk for autism spectrum disorders (ASDs) in children and maternal SSRI
use during pregnancy (doi:10.
To further evaluate whether the observed association between prenatal SSRI
exposure and ASD risk could be attributed to SSRI
treatment rather than to the women's depression or anxiety for which she was prescribed the medication, researchers conducted an analysis of the subgroup of women with a history of mental health disorders in the year before delivery.
2 million), from 1996 to 2009 and graphed the number of prescriptions filled in pharmacies for each SSRI
No actual murders or suicides associated with SSRI
use were reported.
Some of the women were taking SSRIs
, and some weren't; some in each group had a normal CYP2D6 gene, and some carried an enzyme-disabling variant.