SSTRS

Acronym	Definition
SSTRS	Single Solutions Tracking and Reporting System

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NETs are a heterogeneous group of neoplasms that overexpress SSTRs on their cell surface.

The College of Nuclear Physicians of South Africa Practice Guidelines on Peptide Receptor Radionuclide Therapy in Neuroendocrine Tumours

[sup.68]Ga-DOTA peptides bind to SSTRs, in particular SSTR3 and SSTR5, both of which are usually overexpressed in neuroendocrine cells [24].

Grading of Neuroendocrine Carcinomas: Correlation of [sup.68]Ga-PET/CT Scan with Tissue Biomarkers

The choice to target somatostatin receptors is based on the analysis of expression levels of SSTRs in relatively small groups of human corticotroph pituitary adenomas ranging from 1 to 13 cases using RT-PCR [17-22] and the experience that had been gained with inhibitory substances in other endocrine tumors and diseases [21].

High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma

The role of somatostatin receptors (SSTRs) as therapeutic targets in pituitary adenomas is well established.[sup][11] SST analogs are reportedly effective in hormonal control of TSHomas and growth hormones (GH)-secreting adenomas.[sup][1],[12],[13]

Short-term Preoperative Octreotide for Thyrotropin-secreting Pituitary Adenoma

analyzed 199 surgically removed G1-3 pNETs for their SSTRs expression (form type 1 to type 5) and its clinical significance.

Determination of Mammalian Target of Rapamycin Hyperactivation as Prognostic Factor in Well-Differentiated Neuroendocrine Tumors

The expression of 5-H[T.sub.1D]R had a negative correlation with somatostatin (SST) and SST receptors (SSTR), whereas the expression of 5-H[T.sub.2A]R did not have any correlation with either SST or any of the SSTRs; this suggests that increased expression of H[T.sub.1D]R in human islet cells, as observed in T2DM islet cells, leads to decreased expression of SST and its receptors.

Serotonin and Its Receptor as a New Antioxidant Therapeutic Target for Diabetic Kidney Disease

Due to their neuroendocrine origin GEP-NENs express on their cell surface peptide receptors, such as somatostatin receptors (sstr) that can be used for diagnostic, prognostic, and therapeutic purposes [20].

Advances and Current Concepts in the Medical Management of Gastroenteropancreatic Neuroendocrine Neoplasms

Table 2 summarizes the different pathways of SSTR subtype activation.

Peptide receptor targeting in cancer: the somatostatin paradigm

Antibodies used to screen for SSTRs on parasite: Antibodies used to screen for SSTRs on S.

Prolonged somatostatin therapy may cause down-regulation of SSTR-like GPCRs on Schistosoma mansoni

Somatostatin receptors (SSTRs) are variably expressed in neuroblastoma cell lines and tumors, as demonstrated by autoradiography, Western blot, immunohistochemistry, and RT-PCR techniques [17-19].

Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models

They exert biological effects by binding to G protein-coupled receptors known as somatostatin receptors (SSTR), mainly SSTR2 and SSTR5.

Expression of Somatostatin Receptor 2 in Somatotropinoma Correlated with the Short-Term Efficacy of Somatostatin Analogues

The leading clinical application area is oncology with targeted imaging of somatostatin receptors (SSTR), prostate specific membrane antigen (PSMA), integrin receptors, glucagon-like peptide 1 receptors (GLP1R), gastrin-releasing peptide receptors (GRPR), human epidermal growth factor receptor family (HER2), and pretargeted imaging of carcinoembryonic antigen (CEA) [1, 3, 5].

Prospective of [sup.68]Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation