The differentiation between IDA and ssTT is important because of two main reasons, first, because Hb won't improve in ssTT if it is misdiagnosed as IDA and unnecessary iron being prescribed by the attending physician.7 The second grave reason is that misdiagnosed ssTT as IDA may get married to a ssTT, resulting in homozygous or thalassemia major in the offspring.8
Ideally, one needs a battery of tests including detailed peripheral blood picture, Hb A2 estimation, serum iron, Total Iron Binding Capacity (TIBC), serum ferritin and transferrin saturation to differentiate IDA from ssTT clearly.9 But all these tests are either not available in all clinical set ups, or these are relatively time-consuming and expensive techniques.
Mother ss/tt Gametes production St Father Ss/Tt ST STst St Stst sT sTst St Stst In this case, there are two new genetic combinations (Sstt
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