SSUPSSolid State Uninterruptible Power Supply/System
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Depletion of five SSUP proteins (Imp4, Mpp10/Mphosph10, Wdr36, Wdr46, and Wdr75) resulted in a reduction of Nanog expression, and the absence of one SSUP component (Cirh1a) caused cell death.
In ESCs, SSUP subunits are up-regulated which enhances their translation rate and supports the interconnected regulatory network which controls pluripotency.
Furthermore, the SSUP proteins are required for efficient reprogramming of induced pluripotent stem cells.