ST-11

AcronymDefinition
ST-11Intelligent Systems and Software
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(%) Sequence Serogroup, clonal complex isolates type B, n = 38 ST-32 17 (44.7) NA 13 32 2 3822 1 7780 1 9918 ST-41-44 20 (52.6) NA 14 44 1 315 1 8528 2 9233 1 9354 1 10127 ST-461 1 (2.6) NA 1 461 W, n = 60 ST-11 59 (98.3) NA 51 11 7 1025 1 2961 ST-22 1 (1.7) NA 1 184 * NA, not applicable.
Among the 151 isolates analyzed by MLST or PFGE, most were ST-192 (n = 96, 63%), followed by ST-11 (n = 19, 13%), ST-198 (n = 13, 9%), and ST-2881 (n = 8, 6%, including 1 strain with the single locus variant ST-4151) (Table 1).
Serogroup W135 was mostly found in combination with serotype 2a:P1.5,2 and genotype ST-11. Serogroup X was found with NT:P1.5, ST-751, and serogroup Y was found with 14:P1.5,2, ST-4375 (Table 1).
The 19 isolates belonging to ST-11 showed moderate diversity in restriction patterns (Figure 1).
Although most of the ST-2881 isolates belonged to group W135, their PFGE patterns were unrelated to ST-11 isolates in group W135; they were closely related to ST-2881 invasive strains of serogroup W135 found in 2003 in Niger (16).
ST-11, which is usually associated with phenotype W135:2a:P1.5,2 in invasive strains, had phenotype Y:14:P1.5,2 (seen in ST-4375 carriage strains), and ST-4375, which is usually associated with phenotype Y:14: P1.5,2, had phenotype W135:NT:P1.5,2 (seen in ST-11 carriage strains).
Molecular epidemiology of Neisseria meningitidis isolated in the African meningitis belt between 1988 and 2003 shows dominance of sequence type 5 (ST-5) and ST-11 complexes.
ST-2881, which has a possibly lower virulence than the ST-11 strains, should be investigated in mice (14).
Since 2000 and the introduction of ST-11 complex, W135 meningococci among carried isolates in North Africa (Sudan, Morocco) was documented.
The absence of the hyper-virulent W-135 ET ST-11 in returning Singaporean pilgrims from the Hajj 2002 is reflected by an absence of Hajj-associated clinical cases of W-135 disease in Singapore in 2002.
The significant decrease of W-135 meningococcal carriage and the absence of ST-11 in returning pilgrims from the Hajj 2002 are important findings with regard to public health policy.