Also found in: Medical, Wikipedia.
STAT2Signal Transducer and Activator of Transcription 2 (gene)
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
The tumor tissue had higher expressions of IRF7 and STAT2 than the normal tissue in the all subject group (p value 0.003 and 0.01, respectively) and in the subgroup of squamous cell carcinoma (SCC) (p value 0.03 and 0.02, respectively).
We observed that several upregulated genes, including IRF5, IFIT2, DDX3X, STAT1, and STAT2 participate to type I interferon and JAK/STAT signaling pathways.
(10) Thus, NOD1 activation of CXCL9, CXCL10, and CXCL11 transcription via type I IFN requires nuclear translocation of ISGF3, a complex composed of Stat1, Stat2, and IRF9.
DENV NS5 binds and degrades STAT2 by targeting it for ubiquitin-mediated proteasomal degradation [91].
Western blot analysis was performed as described in the literature to evaluate the expressions of STAT1 and STAT2. (24) The ventricles of mice were homogenized in a lysis buffer consisting of 10 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM EDTA, 1 mM sodium-orthovanadate, 20 [micro]M 4-(2-aminoethyl)-benzenesulfonyl fluoride, 0.2% Nonidet P-40, 5 [micro]g/mL leupeptin, and protease inhibitor cocktail (Sigma, St.
Mendez et al., "A Haplotype at STAT2 Introgressed from Neanderthals and Serves as a Candidate of Positive Selection in Papua New Guinea," The American Journal of Human Genetics 91 (2012): 265-74.
In addition, Stat1, Stat2, and Stat3 can form heterodimers.
David, "Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1," Journal of Biological Chemistry, vol.
Difference in phosphorylation of MAPK was observed concerning STaT6, STAT2, and Src that were activated in NHDF and PLC-[gamma], CREB, c-Jun, eNOS, and p70 S6 at T229, respectively, T389 that were solely phosphorylated in NHEK.
The uterine LE/sGE in closest proximity to or adhered to conceptus trophectoderm express these unique genes because IFNT induces expression of IRF2 in uterine LE/sGE to silence expression of ESR1, STAT1, STAT2 and IRF9.
E6 binds to TYK2 preventing binding to the cytoplasmic portion of the IFN receptor inhibiting phosphorylation of TYK2, STAT1, STAT2 impairing JAK STAT activation and therefore inhibiting specifically IFN-[alpha] mediated signalling (64).