Also found in: Medical, Wikipedia.
STAT3Signal Transducer and Activator of Transcription 3 (gene)
References in periodicals archive ?
STAT3 activated and altered macrophages and ultimately resulted in the formation of the abnormal blood vessels.
The team found that STAT3 down regulation, via enhanced expression of PIAS3 or exposure to a peptide derived from PIAS3, inhibited cell growth and increased apoptosis in cancer cells.
Glucocorticoid receptor (GR) and STAT3 binding sites were enriched in the hypomethylated gene regulatory regions in basal/TNBC cell lines, suggesting they may be master transcriptional regulators of this subtype.
STAT3 is another transcription factor that selectively binds to interleukin (IL)-6 to stimulate hepatocytes.
2] Nonstandard abbreviations: BECs, blood endothelial cells; MSCs, mesenchymal stem cells; LECs, lymphatic endothelial cells; CAFs, carcinoma-associated fibroblasts; ECM, extracellular matrix; LOX, lysyl oxidase; BMDCs, bone marrow--derived cells; NK, natural killer cells; MDSCs, myeloid derived suppressor cells; VEGF, vascular endothelial growth factor; PlGF, placental growth factor; MMPs, matrix metalloproteases; MCs, mast cells; Th1, T-helper 1; NF-[kappa]B, nuclear factor [kappa]-light-chain-enhancer of activated B cells; STAT3, signal transducer and activator of transcription 3; IL-1, interleukin 1; FAP, fibroblast activation protein a; ROCK, Rho/Rho-associated protein kinase.
Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.
211,215) STAT3 is directly activated by NPM-ALK through JAK3.
3]-induced pulmonary inflammation via modulation of expression of inflammatory mediators CD86 and MIP-2 and nuclear transcription factors NF-kB and STAT3.
STAT3 may help reduce or increase inflammation in ALD, depending on the specific cell type.