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STAT3 activated and altered macrophages and ultimately resulted in the formation of the abnormal blood vessels.
Crosstalk between cancer and immune cells: role of STAT3 in the tumor microenvironment.
The team found that STAT3 down regulation, via enhanced expression of PIAS3 or exposure to a peptide derived from PIAS3, inhibited cell growth and increased apoptosis in cancer cells.
Glucocorticoid receptor (GR) and STAT3 binding sites were enriched in the hypomethylated gene regulatory regions in basal/TNBC cell lines, suggesting they may be master transcriptional regulators of this subtype.
STAT3 is another transcription factor that selectively binds to interleukin (IL)-6 to stimulate hepatocytes.
2] Nonstandard abbreviations: BECs, blood endothelial cells; MSCs, mesenchymal stem cells; LECs, lymphatic endothelial cells; CAFs, carcinoma-associated fibroblasts; ECM, extracellular matrix; LOX, lysyl oxidase; BMDCs, bone marrow--derived cells; NK, natural killer cells; MDSCs, myeloid derived suppressor cells; VEGF, vascular endothelial growth factor; PlGF, placental growth factor; MMPs, matrix metalloproteases; MCs, mast cells; Th1, T-helper 1; NF-[kappa]B, nuclear factor [kappa]-light-chain-enhancer of activated B cells; STAT3, signal transducer and activator of transcription 3; IL-1, interleukin 1; FAP, fibroblast activation protein a; ROCK, Rho/Rho-associated protein kinase.
Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells.
STAT3 (from Signal Transduction and Activation of Transcription) is a protein that activates certain genes involved in cell differentiation, proliferation and survival.
Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.
211,215) STAT3 is directly activated by NPM-ALK through JAK3.
3]-induced pulmonary inflammation via modulation of expression of inflammatory mediators CD86 and MIP-2 and nuclear transcription factors NF-kB and STAT3.
STAT3 may help reduce or increase inflammation in ALD, depending on the specific cell type.
Acronyms browser ?
- STAT MUX
- STATE DEPT
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- Stat mech
- stat mi
- stat mi
- stat mux
- stat mux
- Stat Unit
- STAT, interleukin4-induced
- STAT-induced SH3 protein 1
- STAT-induced STAT inhibitor 1
- STAT-induced STAT inhibitor 2
- STAT-induced STAT inhibitor 3
- STAT-induced STAT inhibitor-2
- STAT-induced STAT inhibitor-4
- Stat-O-Matic Memorial Baseball League
- STAT1 deficiency, autosomal recessive
- STAT3-interacting protein 1