STAT3


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AcronymDefinition
STAT3Signal Transducer and Activator of Transcription 3 (gene)
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Total serum IgE concentration was measured by using the ImmunoCAP 1000 instrument (Phadia) for both healthy reference samples (n = 1510) and STAT3 patient samples (n = 6).
727] phosphorylation of STAT3 has been described before as part of CA mechanism of action (Liu et al.
Western blot results showed that the total STAT3 protein levels hardly changed, but the p-STAT3 level, detected by the antibodies recognizing the phosphorylation at Y705, was reduced after MCAo operation, and was recovered to some extent in TCZ group (Figure 4A).
Rebuilding the balance of STAT-1 and STAT3 signalings by fusaruside, a cerebroside compound, for the treatment of T-cell-mediated fulminant hepatitis in mice.
Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells," Molecular Medicine Reports, vol.
23) IL-27 activates STAT1 and STAT3 and enhances antitumor cellular and humoral immunity.
These included KRAS, MET, BRAF, mTOR (FRAP1), STAT3, JAK2, PIK3CA, AKT1 through AKT3, and PTEN (Table 1).
Especially in pancreas carcinoma cells, the oncogene STAT3 is over-expressed, leading to the suppression of apoptotic responses.
The p-STAT3 protein is encoded by the STAT3 gene and is unique in the ability both to respond to extracellular signals and to regulate other genes directly.
The interaction between IL-21 and its receptor can induce activation of Janus kinase (JAK)-1 and JAK3 and then activate signal transducers and activators of transcription (STAT) 1 and STAT3.
This is possible because a direct target of nimbolide in prostate cancer is glutathione reductase, an enzyme which is responsible for maintaining the antioxidant system that regulates the STAT3 gene in the body.
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors.